Evidence map›Paper›PMID 33847846›Full record

SynthesisNeurosurgical review2021

Repeat stereotactic radiosurgery for progressive vestibular schwannomas after previous radiosurgery: a systematic review and meta-analysis.

Anne Balossier, Jean Régis, Nicolas Reyns, Pierre-Hugues Roche, Roy Thomas Daniel, Mercy George, Mohamed Faouzi, Marc Levivier, Constantin Tuleasca

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Anne BalossierFunctional, and Stereotactic Neurosurgery Service and Gamma Knife Unit, Assistance Publique - Hôpitaux de Marseille, Timone Hospital, Marseille, France.
Jean RégisFunctional, and Stereotactic Neurosurgery Service and Gamma Knife Unit, Assistance Publique - Hôpitaux de Marseille, Timone Hospital, Marseille, France.
Nicolas ReynsUniversity of Lille, Inserm, CHU de Lille, U1189 - ONCO-THAI -Laser Assisted Therapies and Immunotherapies for Oncology, F-59000, Lille, France.
Pierre-Hugues RocheNeurosurgery Service, Neurochirurgie Hôpital Nord, Pôle NEUROSCIENCES, Hôpital Nord, Marseille, France.
Roy Thomas DanielDepartment of Clinical Neurosciences, Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Mercy GeorgeDepartment of Otorhinolaryngology, Head & Neck Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Mohamed FaouziDivision of Biostatistics, Center for Primary Care and Public Health (Unisanté), Université de Lausanne, Lausanne, Switzerland.
Marc LevivierDepartment of Clinical Neurosciences, Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Constantin TuleascaDepartment of Clinical Neurosciences, Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. constantin.tuleasca@chuv.ch.ORCID http://orcid.org/0000-0001-6776-1486
University Hospital of Lausanne · CHInserm · FRCentre universitaire de médecine générale et santé publique, Lausanne · CHHôpital Nord · FR

Funding

Université de Lausanne Jeune Chercheur en Recherche Clinique
6 · The paper itself

Abstract

Vestibular schwannomas (VS) are slow-growing intracranial extraaxial benign tumors, developing from the vestibular part of the eight cranial nerves. Stereotactic radiosurgery (SRS) has now a long-term scientific track record as first intention treatment for small- to medium-sized VS. Though its success rate is very high, SRS for VS might fail to control tumor growth in some cases. However, the literature on repeat SRS after previously failed SRS remains scarce and reported in a low number of series with a limited number of cases. Here, we aimed at performing a systematic review and meta-analysis of the literature on repeat SRS for VS. Using PRISMA guidelines, we reviewed manuscripts published between January 1990 and October 2020 and referenced in PubMed. Tumor control and cranial nerve outcomes were evaluated with separate meta-analyses. Eight studies comprising 194 patients were included. The overall rate of patients treated in repeat SRS series as per overall series with first SRS was 2.2% (range 1.2-3.2%, p < 0.001). The mean time between first and second SRS was 50.7 months (median 51, range 44-64). The median marginal dose prescribed at first SRS was 12 Gy (range 8-24) and at second SRS was 12 Gy (range 9.8-19). After repeat SRS, tumor stability was reported in 61/194 patients, i.e., a rate of 29.6% (range 20.2-39%, I

Indexed as

Neuroma, AcousticRadiosurgeryFacial NerveFollow-Up StudiesHumansRetrospective StudiesTreatment OutcomeCochlear nerveFacial nerveGamma KnifeHearingStereotactic radiosurgeryVestibular schwannoma

Identifiers

PMID33847846
PMCPMC8592961
OpenAlexW3152958379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.