ReviewEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2022
Mitigating the stress response to improve outcomes for older patients undergoing emergency surgery with the addition of beta-adrenergic blockade.
Review in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Impact of Beta-Blocker Therapy for Cardiovascular Diseases on Bone Healing Following Fracture Surgery.Calcified tissue international · 2026Review
- Comparative outcomes of transcatheter arterial embolization versus open surgery for blunt abdominal solid organ injury with concurrent traumatic brain injury.Scientific reports · 2025Observational
- Efficacy of beta-blockers in the treatment of hematidrosis: A systematic review.World journal of experimental medicine · 2025Article
- European society for trauma and emergency surgery member-identified research priorities in emergency surgery: a roadmap for future clinical research opportunities.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Review
- The relationship and predictive value of dementia and frailty for mortality in patients with surgically managed hip fractures.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Investigating the link between frailty and outcomes in geriatric patients with isolated rib fractures.Trauma surgery & acute care open · 2024Article
- The mortality burden of frailty in hip fracture patients: a nationwide retrospective study of cause-specific mortality.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- A nationwide analysis on the interaction between frailty and beta-blocker therapy in hip fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Article
- Predictors of outcomes in geriatric patients with moderate traumatic brain injury after ground level falls.Frontiers in medicine · 2023Article
- Mortality risk stratification in isolated severe traumatic brain injury using the revised cardiac risk index.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Dementia is a surrogate for frailty in hip fracture mortality prediction.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Adipose tissue: a neglected organ in the response to severe trauma?Cellular and molecular life sciences : CMLS · 2022Review
- Mode of anesthesia is not associated with outcomes following emergency hip fracture surgery: a population-level cohort study.Trauma surgery & acute care open · 2022Article
- Developing and validating a scoring system for measuring frailty in patients with hip fracture: a novel model for predicting short-term postoperative mortality.Trauma surgery & acute care open · 2022Article
- Neuroimmunology of cancer and associated symptomology.Immunology and cell biology · 2021Review
- Article
- S-ketamine plus dexmedetomidine vs. S-ketamine plus propofol for sedation-analgesia during positioning for spinal anesthesia in older adults undergoing lower extremity fracture surgery.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As population age, healthcare systems and providers are likely to experience a substantial increase in the proportion of elderly patients requiring emergency surgery. Emergency surgery, compared with planned surgery, is strongly associated with increased risks of adverse postoperative outcomes due to the short time available for diagnosis, optimization, and intervention in patients presenting with physiological derangement. These patient populations, who are often frail and burdened with a variety of co-morbidities, have lower reserves to deal with the stress of the acute condition and the required emergency surgical intervention. In this review article, we discuss topical areas where mitigation of the physiological stress posed by the acute condition and asociated surgical intervention may be feasible. We consider the impact of the adrenergic response and use of beta blockers for these high-risk patients and discuss common risk factors such as frailty and delirium. A proactive multidisciplinary approach to peri-operative care aimed at mitigation of the stress response and proactive management of common conditions in the older emergency surgical patient could yield more favorable outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.