ArticleAmerican journal of epidemiology2021
Congenital Malformations and Perinatal Deaths Among the Children of Atomic Bomb Survivors: A Reappraisal.
Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 42 citations in OpenAlex.
- Prenatal computed tomography (CT) and risk of congenital heart disease and cerebral palsy: A nationwide mother-child paired cohort study.BMC medicine · 2026Article
- Interpretation of Confounding in Atomic Bomb Radiation Risk Studies.Journal of epidemiology · 2026Article
- Detection of germline variants in human population chronically exposed to high level natural background radiation in Kerala coast.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2026Article
- Behavioural changes in high school students and their parents, following their participation in seminars on discrimination and prejudice regarding radiation exposure: a qualitative study on the 'GU-GU-RU' project.BMC public health · 2025Article
- The importance of data from the atomic bomb survivors for international radiological protection.Carcinogenesis · 2025Article
- Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring.Carcinogenesis · 2025Review
- Symposium report-ethical and social considerations regarding return of secondary findings in atomic bomb survivors.Carcinogenesis · 2025Article
- Eight decades of research on the long-term health effects of radiation in atomic bomb survivors and their offspring.Carcinogenesis · 2025Review
- Evidence for a transgenerational mutational signature from ionizing radiation exposure in humans.Scientific reports · 2025Article
- False and Misleading Claims of Scientific Misconduct in Early Research into Radiation Dose-response: Part 1. Overlooking Key Historical Text.Health physics · 2025Article
- Article
- Population Studies and Molecular Mechanisms of Human Radioadaptive Capabilities: Is It Time to Rethink Radiation Safety Standards?International journal of molecular sciences · 2024Review
- A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure.Radiation research · 2024Review
- 2022 Fukushima Medical University International Symposium on the Fukushima Health Management Survey Build Back Better, Together. "Science for Society: Advancing Fukushima's Well-Being".Fukushima journal of medical science · 2024Article
- Evaluation of risk due to chronic low dose ionizing radiation exposure on the birth prevalence of congenital heart diseases (CHD) among the newborns from high-level natural radiation areas of Kerala coast, India.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2022Article
- Effects of External Radiation Exposure on Perinatal Outcomes in Pregnant Women After the Fukushima Daiichi Nuclear Power Plant Accident: the Fukushima Health Management Survey.Journal of epidemiology · 2022Article
- Yamada et al. Respond to "Radiation and Reproductive Health".American journal of epidemiology · 2021Article
- Areas of research to support the system of radiological protection.Radiation and environmental biophysics · 2021Review
- The LNT Model and ALARA in Diagnostic Imaging: A Critical Review of Scientific Evidence in the Low-Dose Range.Dose-response : a publication of International Hormesis SocietyReview
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From 1948 to 1954, the Atomic Bomb Casualty Commission conducted a study of pregnancy outcomes among births to atomic bomb survivors (Hiroshima and Nagasaki, Japan) who had received radiation doses ranging from 0 Gy to near-lethal levels. Past reports (1956, 1981, and 1990) on the cohort did not identify significant associations of radiation exposure with untoward pregnancy outcomes, such as major congenital malformations, stillbirths, or neonatal deaths, individually or in aggregate. We reexamined the risk of major congenital malformations and perinatal deaths in the children of atomic bomb survivors (n = 71,603) using fully reconstructed data to minimize the potential for bias, using refined estimates of the gonadal dose from Dosimetry System 2002 and refined analytical methods for characterizing dose-response relationships. The analyses showed that parental exposure to radiation was associated with increased risk of major congenital malformations and perinatal death, but the estimates were imprecise for direct radiation effects, and most were not statistically significant. Nonetheless, the uniformly positive estimates for untoward pregnancy outcomes among children of both maternal and paternal survivors are useful for risk assessment purposes, although extending them to populations other than the atomic bomb survivors comes with uncertainty as to generalizability.
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Registered trials
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