Evidence map›Paper›PMID 33847345›Full record

ArticleThe Journal of nutrition2021

Diet Modulates the Effects of Genetic Variants on the Vitamin D Metabolic Pathway and Bone Mineral Density in Mexican Postmenopausal Women.

Berenice Rivera-Paredez, Amado D Quezada-Sánchez, Edgar Denova-Gutiérrez, Leticia Torres-Ibarra, Yvonne N Flores, Jorge Salmerón, Rafael Velázquez-Cruz

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Berenice Rivera-ParedezResearch Center in Policies, Population, and Health, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID 0000-0002-9845-024X
Amado D Quezada-SánchezCenter for Evaluation and Surveys Research, National Institute of Public Health, Cuernavaca, Mexico.
Edgar Denova-GutiérrezCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Leticia Torres-IbarraCenter for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Yvonne N FloresEpidemiology and Health Services Research Unit, Mexican Institute of Social Security, Cuernavaca, Morelos, Mexico.
Jorge SalmerónResearch Center in Policies, Population, and Health, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Rafael Velázquez-CruzGenomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico.ORCID 0000-0003-4515-0777
Instituto Nacional de Salud Pública · MXUniversidad Nacional Autónoma de México · MXKaiser Permanente · USNational Institute of Genomic Medicine · MX

Funding

Genetic and Environmental Risk of Liver Disease/Cancer among MexicansK07CA197179 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FLORES, YVONNE NICOLE · 2015 to 2019
$805k
NCI NIH HHS K07 CA197179
6 · The paper itself

Abstract

backgroundMacro- and micronutrients, such as proteins, vitamin D, and calcium (Ca), are important dietary factors that can modify bone mineral density (BMD). Genetic factors can interact with diet, affecting an individual's predisposition to osteoporosis.

objectivesThis study aimed to evaluate the associations between macro- and micronutrient intakes and BMD in Mexican postmenopausal women, and their interactions with genetic polymorphisms involved in the vitamin D metabolic pathway.

methodsWe analyzed data from 317 postmenopausal women from the Health Workers Cohort Study, a longitudinal cohort studied in Cuernavaca, Mexico. Postmenopausal women participated in 2 data collection waves (2004-2006 and 2010-2011), with a mean time of 6.4 years. Dietary intake was assessed with a semi-quantitative FFQ. BMD (femoral neck, hip, and lumbar spine) was measured by DXA. Hybrid mixed-effects regression models were used to assess the associations of dietary macro- and micronutrients on BMD, after adjusting for confounding factors and for diet and single nucleotide polymorphism interactions.

resultsAt baseline, the median age was 57 years (IQR, 50-64). Mean femoral neck, hip, and lumbar spine BMDs decreased over time. We observed statistically significant longitudinal associations for diet (Ca, vitamin D, magnesium, phosphorus, and protein intake) and BMD. Increases of vitamin D, Ca, and protein intakes by 1 SD were associated with mean increases in the femoral neck BMD (0.083 SD, 0.064 SD, and 0.130 SD, respectively). Multiple significant interactions were identified between several loci (CYP2R1, CYP24A1, CYP27B1, VDR, and DHCR7/NADSYN1) and diet for BMDs (femoral neck, hip, and lumbar spine), mainly for protein intake.

conclusionsOur data support associations of vitamin D, Ca, protein, phosphorous, and magnesium consumption with BMD in Mexican postmenopausal women and suggest possible gene-diet interactions. These results could facilitate future personalized nutrition recommendations to help prevent low BMD.

Indexed as

Bone DensityOsteoporosis, PostmenopausalCohort StudiesDietFemaleHumansMetabolic Networks and PathwaysMexicoMiddle AgedPolymorphism, Single NucleotidePostmenopauseVitamin DVitamin Dbone mineral densitygene-diet interactionmacronutrientsmicronutrientsvitamin D

Identifiers

PMID33847345
PMCPMC8277435
OpenAlexW3153595117

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.