Evidence map›Paper›PMID 33847295›Full record

ArticleThe Pediatric infectious disease journal2021

Outcomes of Children Born to Pregnant Women With Drug-resistant Tuberculosis Treated With Novel Drugs in Khayelitsha, South Africa: A Report of Five Patients.

Rebecca Acquah, Erika Mohr-Holland, Johnny Daniels, Jennifer Furin, Marian Loveday, Vanessa Mudaly, Anja Reuter

Open access · hybridAbstract readCase Reports
In one paragraph

Article in The Pediatric infectious disease journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Pregnancy and Birth Outcomes in Patients With Multidrug-Resistant Tuberculosis Treated With Regimens That Include New and Repurposed Drugs.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  7. Favourable outcomes in RR-TB patients using BPaL and other WHO-recommended second-line anti-TB drugs.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
    Article
  8. Best practices for the care of pregnant people living with TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
    Review
  9. Considerations for the Use of Long-Acting and Extended-Release Agents During Pregnancy and Lactation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  10. Safety of Antimicrobials for Postexposure Prophylaxis and Treatment of Anthrax: A Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Rebecca AcquahFrom the Médecins Sans Frontières, Khayelitsha, Cape Town, South Africa.
Erika Mohr-HollandFrom the Médecins Sans Frontières, Khayelitsha, Cape Town, South Africa.
Johnny DanielsFrom the Médecins Sans Frontières, Khayelitsha, Cape Town, South Africa.
Jennifer FurinDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, MA.
Marian LovedayHealth Systems Research Unit, South African Medical Research Council, KwaZulu-Natal, South Africa.
Vanessa MudalyDepartment of Health, Province of the Western Cape, Cape Town, South Africa.
Anja ReuterFrom the Médecins Sans Frontières, Khayelitsha, Cape Town, South Africa.
Médecins Sans Frontières · ZAHarvard Global Health Institute · USSouth African Medical Research Council · ZAWestern Cape Department of Health · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This brief report presents a series of 5 pregnant women treated for rifampicin-resistant tuberculosis with the novel drugs bedaquiline, delamanid, and linezolid as part of an optimized backbone regimen and reviews the outcomes of the children born to them. Although the case series is small, all children had excellent birth outcomes suggesting pregnant women should not be denied access to novel therapies for RR-TB.

Indexed as

Pregnant PeopleAdultAntitubercular AgentsChild HealthChild, PreschoolDiarylquinolinesFemaleHumansInfantInfant HealthLinezolidNitroimidazolesOxazolesPregnancyPregnancy OutcomeSouth AfricaAntitubercular AgentsbedaquilineDiarylquinolinesLinezolidNitroimidazolesOPC-67683Oxazoles

Identifiers

PMID33847295
PMCPMC8043512
OpenAlexW3134323882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.