Evidence map›Paper›PMID 33846802›Full record

Observational studyOncology reports2021

Long non‑coding RNA MIR4435‑2HG promotes the progression of head and neck squamous cell carcinoma by regulating the miR‑383‑5p/RBM3 axis.

Shu Wang, Xianfeng Chen, Tiankui Qiao

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Regulation of Ferroptosis by Non-Coding RNAs in Head and Neck Cancers.International journal of molecular sciences · 2022
    Review
  12. MicroRNA-383: A tumor suppressor miRNA in human cancer.Frontiers in cell and developmental biology · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Cytotoxicity of curcumin against CD44Avicenna journal of phytomedicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shu WangCenter for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. China.
Xianfeng ChenDepartment of Pharmacy, Tinglin Hospital, Shanghai 201505, P.R. China.
Tiankui QiaoCenter for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, Shanghai 201508, P.R. China.
Jinshan Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have shown that long non‑coding RNAs (lncRNAs) are strongly related to the progression of various types of cancer. The lncRNA MIR4435‑2 host gene (MIR4435‑2HG) has been recently recognized as a tumor‑related lncRNA that is upregulated in several tumors. However, its possible functions in head and neck squamous cell carcinoma (HNSCC) remain unclear. In tShe present study, we observed that MIR4435‑2HG expression was markedly upregulated in HNSCC tissues based on a Gene Expression Profiling Interactive Analysis dataset. This result was further confirmed in HNSCC tissues and cell lines using quantitative real‑time polymerase chain reaction. In addition, the high expression level of MIR4435‑2HG was significantly associated with poor disease‑free survival and overall survival in all HNSCC cases and was associated with advanced tumor‑metastasis‑node stage and poor prognosis.

Indexed as

AdultAgedApoptosisCell Line, TumorCell ProliferationDatasets as TopicDiseaseEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHead and Neck NeoplasmsHumansMaleMicroRNAsMiddle AgedMicroRNAsMIR4435-2HG long non-coding RNA, humanMIRN383 microRNA, humanRBM3 protein, humanRNA-Binding ProteinsRNA, Long Noncodingcell migrationcell proliferationepithelial–mesenchymal transitionhead and neck squamous cell carcinomamiR‑383‑5p/RBM3MIR4435‑2HG

Identifiers

PMID33846802
PMCPMC8054316
OpenAlexW3156616725

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.