SynthesisJournal of rehabilitation medicine2021
Effectiveness of total knee arthroplasty rehabilitation programmes: A systematic review and meta-analysis.
Synthesis in Journal of rehabilitation medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06945926 (The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery：Two-Stage Designs for Phase II Clinical Trials), which is not on this map. Cited by 42 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery：Two-Stage Designs for Phase II Clinical Trials
Who cites it
42 citing papers in PubMed, 7 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Registration and reporting characteristics of trials investigating exercise therapy following total knee arthroplasty: a systematic review.Acta orthopaedica · 2026Pooled it
- Comparison of conventional and minimally invasive approaches of primary total knee arthroplasty: a network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2026Pooled it
- Changes in knee outcome measures following later-stage exercise interventions implemented ≤ 12 weeks vs. > 12 weeks after total knee arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Pharmacologic pain management strategies for reducing postoperative pain in total knee arthroplasty: a systematic review from molecular mechanisms to clinical efficiency.Archives of orthopaedic and trauma surgery · 2025Pooled it
- Continuous femoral nerve block as pain management following total knee arthroplasty: a systematic review.Archives of orthopaedic and trauma surgery · 2025Pooled it
- Effectiveness of home-based exercise interventions on pain, physical function and quality of life in individuals with knee osteoarthritis: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- A systematic review and meta-analysis comparing outcomes following total knee arthroplasty for rheumatoid arthritis versus for osteoarthritis.BMC musculoskeletal disorders · 2023Pooled it
- Feasibility of a randomized trial comparing exercise-based rehabilitation to no exercise-based rehabilitation after total knee arthroplasty: DRAW-TKA hybrid 1 RCT.Osteoarthritis and cartilage open · 2026Trial
- Significance of a 4-week home-based prehabilitation program in accelerating 3-month recovery post total knee arthroplasty: a retrospective cohort study.Knee surgery & related research · 2026Article
- Timing Matters: Early Versus Delayed Rehabilitation After Total Knee Arthroplasty and Its Impact on Functional Recovery-A Systematic Review.Journal of functional morphology and kinesiology · 2026Review
- Risk of periprosthetic joint infection within 1 year following robotic-assisted versus conventional primary total knee arthroplasty: a propensity-score-matched cohort study.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026Article
- Effectiveness of inpatient versus outpatient rehabilitation following total knee arthroplasty on clinical and functional outcomes in Germany: a non-randomized clinical trial.BMC sports science, medicine & rehabilitation · 2026Article
- Consolidation of Publicly Funded Outpatient Musculoskeletal Physiotherapy Services in Winnipeg, Manitoba: Effects on Accessibility and Service Delivery.Physiotherapy Canada. Physiotherapie Canada · 2026Article
- Association between sustained opioid use and survival or major adverse cardiovascular events after total knee arthroplasty: evidence from a population-based cohort.BMC anesthesiology · 2026Article
- Robot-assisted total knee arthroplasty is associated with reduced early anterior knee pain compared with conventional techniques : A propensity score-matched study.Orthopadie (Heidelberg, Germany) · 2026Article
- Effects of physical therapy modalities for early postoperative pain following total knee arthroplasty: a systematic review and network meta-analysis.Frontiers in rehabilitation sciences · 2026Review
- Influence of qNOX-guided remifentanil titration on intraoperative dosing and postoperative pain in total knee arthroplasty: a pilot randomized trial.Journal of anesthesia, analgesia and critical care · 2025Article
- Knee extensor muscle strength, physical function and patient-reported outcomes the first year after total knee arthroplasty: a prospective longitudinal study.BMC musculoskeletal disorders · 2025Observational
- Postoperative anterior knee pain in robot assisted total knee arthroplasty: a propensity score matching analysis.Surgery in practice and science · 2025Article
- Esketamine alleviated cardiomyocyte ferroptosis induced by oxygen-glucose deprivation/reoxygenation (OGD/R) via cyclic GMP-AMP synthase interactor.Cytotechnology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effectiveness of modified rehabilitation programmes in comparison with standard rehabilitation programmes after total knee arthroplasty through randomized controlled trials. DATA SOURCES: A search was conducted in PubMed, PubMed Central (PMC) and Cochrane Library databases in December 2020. STUDY SELECTION: Randomized controlled trials were reviewed if they compared a physiotherapy exercise intervention with usual or standard physiotherapy care, or if they compared 2 types of exercise physiotherapy interventions meeting the review criteria, after total knee arthroplasty for osteoarthritis. A total of 18 randomized controlled trials were included at the end of the screening process. DATA EXTRACTION: Two authors independently screened the literature, extracted data, and assessed the quality of included studies. The outcomes were knee extension, knee flexion, pain visual analogue scale, overall Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), 6-minute walking test, and Timed Up and Go test. DATA SYNTHESIS: There was no clear pattern regarding which combination of starting time-point and duration of the rehabilitation programme after total knee arthroplasty significantly improves the clinical outcome when comparing modified rehabilitation programmes with standard programmes. Moreover, no particular modification to the modified programmes could be solely attributed to the improved clinical outcome in the 2 studies that showed significant improvement.
conclusionModified rehabilitation programmes do not result in systematic improvement in clinical outcome over one-size-fits-all-approaches after total knee arthroplasty.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.