ArticleNature genetics2021
Whole-genome resequencing of 445 Lactuca accessions reveals the domestication history of cultivated lettuce.
Article in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- Plant genetic and root-associated microbial diversity modulate Lactuca sativa responsiveness to a soil inoculum under phosphate deficiency.The New phytologist · 2026Article
- Matching circadian rhythms to light-dark cycles increases lettuce yield by 29% in vertical farms without additional energy input.Journal of experimental botany · 2026Article
- Integrated Metabolomics and Selection Signal Analysis Provide Insights Into the Selection for Flavonol Biosynthesis Associated With Lettuce Quality Improvement.Plant biotechnology journal · 2026Article
- KCFtools: rapid alignment-free method for introgression screening and GWAS using k-mer profiles.Bioinformatics (Oxford, England) · 2026Article
- LsMAPK6 Phosphorylates the LsCO Protein to Enhance Its Stability and Transcriptional Activity, Promoting Floral Transition Upon High Temperatures in Lettuce.Plant biotechnology journal · 2026Article
- Insights into lentil diversity, domestication, and the genetic basis of important agronomic traits through resequencing of 238 Lens accessions.The Plant journal : for cell and molecular biology · 2026Article
- A Rapid Hairy Root-Based Platform for CRISPR/Cas Optimization and Guide RNA Validation in Lettuce.Plants (Basel, Switzerland) · 2026Article
- Identification of photosynthetic pigment content-related genes in peanut (Arachis hypogaea L.) by GWAS and RNA-seq.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Plant phenotypic differentiation outweighs genetic variation in shaping the lettuce leaf microbiota.Environmental microbiome · 2026Article
- Genome-wide association study in a lettuce core collection from 811 accessions reveals genetic loci for anthocyanin accumulation and cultivar development.Horticulture research · 2026Article
- Continuous light at fixed daily light integral enhances lettuce growth due to improved light interception and light use efficiency.Frontiers in plant science · 2026Article
- Genome-Wide, High-Density Genotyping Approaches for Plant Germplasm Characterisation (Methods and Applications).International journal of molecular sciences · 2025Review
- Evolution of terpene synthases in the sesquiterpene biosynthesis pathway and analysis of their transcriptional regulatory network in Asteraceae.Horticulture research · 2025Article
- Unraveling the variation, phylogeny, and taxonomy of Lactuca spp. for germplasm management and breeding.Planta · 2025Review
- Breeding for delayed bolting decelerated the circadian clock in cultivated lettuce.The New phytologist · 2025Article
- Signatures in domesticated beet genomes pointing at genes under selection in a sucrose-storing root crop.BMC biology · 2025Article
- Integration of crop modeling and sensing into molecular breeding for nutritional quality and stress tolerance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Lactuca super-pangenome provides insights into lettuce genome evolution and domestication.Nature communications · 2025Article
- From aerial drone to quantitative trait locus: leveraging next-generation phenotyping to reveal the genetics of color and height in field-grown Lactuca sativa.The Plant journal : for cell and molecular biology · 2025Article
- Genome-wide locus-allele comparison reveals differential evolution dynamics from annual wild to landrace and released cultivar soybeans.The plant genome · 2025Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lettuce (Lactuca sativa) is an important vegetable crop worldwide. Cultivated lettuce is believed to be domesticated from L. serriola; however, its origins and domestication history remain to be elucidated. Here, we sequenced a total of 445 Lactuca accessions, including major lettuce crop types and wild relative species, and generated a comprehensive map of lettuce genome variations. In-depth analyses of population structure and demography revealed that lettuce was first domesticated near the Caucasus, which was marked by loss of seed shattering. We also identified the genetic architecture of other domestication traits and wild introgressions in major resistance clusters in the lettuce genome. This study provides valuable genomic resources for crop breeding and sheds light on the domestication history of cultivated lettuce.
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