ArticleNature neuroscience2021
Flexible modulation of sequence generation in the entorhinal-hippocampal system.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Dynamic Hippocampal-Striatal Information Flow Accompanies Behavioral Strategy Transitions During Sequential Learning in Pigeons: A Preliminary Study.Animals : an open access journal from MDPI · 2026Article
- Drift-diffusion dynamics of hippocampal replay.PLoS computational biology · 2026Article
- The hippocampus as a small-world cognitive map.bioRxiv : the preprint server for biology · 2026Article
- Dynamical modulation of hippocampal replay through firing rate adaptation.Nature communications · 2026Article
- Article
- Non-human primates can flexibly learn serial sequences and reorder context-dependent object sequences.PLoS biology · 2025Article
- Empowering safer socially sensitive autonomous vehicles using human-plausible cognitive encoding.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- On the varieties of conscious experiences: Altered Beliefs Under Psychedelics (ALBUS).Neuroscience of consciousness · 2025Article
- Flexible Learning and Re-ordering of Context-dependent Object Sequences in Nonhuman Primates.bioRxiv : the preprint server for biology · 2024Article
- Distributed and dynamical communication: a mechanism for flexible cortico-cortical interactions and its functional roles in visual attention.Communications biology · 2024Article
- Hippocampal sequences span experience relative to rewards.bioRxiv : the preprint server for biology · 2024Article
- Binding in hippocampal-entorhinal circuits enables compositionality in cognitive maps.Advances in neural information processing systems · 2024Article
- Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception.Brain : a journal of neurology · 2023Review
- Trajectories through semantic spaces in schizophrenia and the relationship to ripple bursts.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- A model of hippocampal replay driven by experience and environmental structure facilitates spatial learning.eLife · 2023Article
- Neural network based formation of cognitive maps of semantic spaces and the putative emergence of abstract concepts.Scientific reports · 2023Article
- Distinct replay signatures for prospective decision-making and memory preservation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Imagination as a fundamental function of the hippocampus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Compositional Sequence Generation in the Entorhinal-Hippocampal System.Entropy (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Exploration, consolidation and planning depend on the generation of sequential state representations. However, these algorithms require disparate forms of sampling dynamics for optimal performance. We theorize how the brain should adapt internally generated sequences for particular cognitive functions and propose a neural mechanism by which this may be accomplished within the entorhinal-hippocampal circuit. Specifically, we demonstrate that the systematic modulation along the medial entorhinal cortex dorsoventral axis of grid population input into the hippocampus facilitates a flexible generative process that can interpolate between qualitatively distinct regimes of sequential hippocampal reactivations. By relating the emergent hippocampal activity patterns drawn from our model to empirical data, we explain and reconcile a diversity of recently observed, but apparently unrelated, phenomena such as generative cycling, diffusive hippocampal reactivations and jumping trajectory events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.