Evidence map›Paper›PMID 33846611›Full record

ReviewNature medicine2021

Vaccine development for emerging infectious diseases.

Jean-Louis Excler, Melanie Saville, Seth Berkley, Jerome H Kim

5 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 191 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05508477 phase3unknown statusnot on this mapstarted 2022, after this paper: background citation

A Multicenter, Randomized, Double Blind, Controlled, Phase III Clinical Trial (Immunobridging Study) of Vaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) in Healthy Population Aged 18 Years and Above

TypeinterventionalSponsorDr. Soetomo General HospitalRan2022 to 2023Enrolled4,005ConditionsCOVID-19 Pandemic, COVID-19 VaccinesArmsVaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) 5 µg, CoronaVac Biofarma COVID-19 Vaccine
NCT05918939 early_phase1unknown statusnot on this mapstarted 2022, after this paper: background citation

Immunobridging Study: Immunogenicity and Safety of Vaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) Vaccine as Heterologue Booster in Adult Subjects in Indonesia

TypeinterventionalSponsorDr. Soetomo General HospitalRan2022 to 2023Enrolled350ConditionsCOVID-19 Pandemic, COVID-19 VaccinesArmsVaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) 5 µg, CoronaVac Biofarma COVID-1 9 Vaccine 3 µg
NCT06259578 early_phase1unknown statusnot on this mapstarted 2024, after this paper: background citation

Immunobridging Study: Immunogenicity and Safety of INAVAC (Vaksin Merah Putih - UNAIR SARS-CoV-2 (Vero Cell Inactivated)) Vaccine as Homologue Booster in Adult Subjects in Indonesia

TypeinterventionalSponsorDr. Soetomo General HospitalRan2024 to 2024Enrolled400ConditionsCOVID-19 Pandemic, COVID-19 Vaccines, COVID-19 Virus DiseaseArmsINAVAC (Vaksin Merah Putih - UA- SARS CoV-2 (Vero Cell Inactivated) 5 μg
NCT06272253 early_phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Immunobridging Study: Immunogenicity and Safety of INAVAC (Vaksin Merah Putih - UNAIR SARS-CoV-2 (Vero Cell Inactivated)) as Heterologue Booster in Adolescent Subjects in Indonesia

TypeinterventionalSponsorDr. Soetomo General HospitalRan2023 to 2024Enrolled250ConditionsCOVID-19 Pandemic, COVID-19 VaccinesArmsINAVAC (Vaksin Merah Putih - UA- SARS CoV-2 (Vero Cell Inactivated) 5 μg
NCT06282692 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

An Open Label, Phase III Clinical Trial (Immunobridging Study) of INAVAC (Vaksin Merah Putih - UA-SARS CoV-2 (Vero Cell Inactivated)) in Healthy Population Aged 12 to 17 Years Old

TypeinterventionalSponsorDr. Soetomo General HospitalRan2023 to 2024Enrolled400ConditionsCOVID-19 Pandemic, COVID-19 VaccinesArmsINAVAC (Vaksin Merah Putih - UA-SARS CoV-2 (Vero Cell Inactivated) 5 µg
3 · Its place in the literature

Who cites it

191 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Human Organoids as a Novel Tool for Vaccine Study.Advanced healthcare materials · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Global vaccine development.Nature medicine · 2026
    Review
  8. Article
  9. Polysaccharide Extracted from Longan (International journal of molecular sciences · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Introduction to the Immune System.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  20. Article

131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jean-Louis ExclerInternational Vaccine Institute, Seoul, Republic of Korea. Jeanlouis.excler@ivi.int.ORCID http://orcid.org/0000-0002-6462-5101
Melanie SavilleCoalition for Epidemic Preparedness Innovations (CEPI), London, UK.
Seth BerkleyGavi, the Vaccine Alliance, Geneva, Switzerland.
Jerome H KimInternational Vaccine Institute, Seoul, Republic of Korea. Jerome.kim@ivi.int.ORCID http://orcid.org/0000-0003-0461-6438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Examination of the vaccine strategies and technical platforms used for the COVID-19 pandemic in the context of those used for previous emerging and reemerging infectious diseases and pandemics may offer some mutually beneficial lessons. The unprecedented scale and rapidity of dissemination of recent emerging infectious diseases pose new challenges for vaccine developers, regulators, health authorities and political constituencies. Vaccine manufacturing and distribution are complex and challenging. While speed is essential, clinical development to emergency use authorization and licensure, pharmacovigilance of vaccine safety and surveillance of virus variants are also critical. Access to vaccines and vaccination needs to be prioritized in low- and middle-income countries. The combination of these factors will weigh heavily on the ultimate success of efforts to bring the current and any future emerging infectious disease pandemics to a close.

Indexed as

Cholera VaccinesCommunicable Diseases, EmergingCOVID-19COVID-19 VaccinesDengue VaccinesHealth Services AccessibilityHumansPharmacovigilanceSARS-CoV-2Typhoid-Paratyphoid VaccinesVaccinesYellow Fever VaccineCholera VaccinesCOVID-19 VaccinesDengue VaccinesTyphoid-Paratyphoid VaccinesVaccinesYellow Fever Vaccine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.