Evidence map›Paper›PMID 33846600›Full record

ReviewNature reviews. Microbiology2021

Examining horizontal gene transfer in microbial communities.

Ilana Lauren Brito

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed
39.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed, 390 citations in OpenAlex.

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  6. Antimicrobial Resistance Under a Changing Climate.Journal of the Royal Society of New Zealand · 2026
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157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ilana Lauren BritoMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. ibrito@cornell.edu.ORCID http://orcid.org/0000-0002-2250-3480
Cornell University · US

Funding

Systems-Level Perspectives of Horizontal Gene Transfer Within the Human MicrobiomeDP2HL141007 · NHLBI · CORNELL UNIVERSITY · PI BRITO, ILANA LAUREN · 2017 to 2020
$2.6M
NHLBI NIH HHS DP2 HL141007
6 · The paper itself

Abstract

Bacteria acquire novel DNA through horizontal gene transfer (HGT), a process that enables an organism to rapidly adapt to changing environmental conditions, provides a competitive edge and potentially alters its relationship with its host. Although the HGT process is routinely exploited in laboratories, there is a surprising disconnect between what we know from laboratory experiments and what we know from natural environments, such as the human gut microbiome. Owing to a suite of newly available computational algorithms and experimental approaches, we have a broader understanding of the genes that are being transferred and are starting to understand the ecology of HGT in natural microbial communities. This Review focuses on these new technologies, the questions they can address and their limitations. As these methods are applied more broadly, we are beginning to recognize the full extent of HGT possible within a microbiome and the punctuated dynamics of HGT, specifically in response to external stimuli. Furthermore, we are better characterizing the complex selective pressures on mobile genetic elements and the mechanisms by which they interact with the bacterial host genome.

Indexed as

Gene Transfer, HorizontalMicrobiotaAnimalsBacteriaBacterial Physiological PhenomenaHumansPolymerase Chain ReactionSelection, Genetic

Identifiers

PMID33846600
OpenAlexW3155905513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.