Evidence map›Paper›PMID 33846437›Full record

ArticleScientific reports2021

Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells.

Xiaoxia Song, Zhi Chen, Xue Zhang, Junfeng Xiong, Teng Jiang, Zihan Wang, Xinran Geng, U Kei Cheang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Treatment of lung diseasesMaterials today. Bio · 2025
    Review
  7. Review
  8. A Lifetime of Catalytic Micro-/Nanomotors.Nanomaterials (Basel, Switzerland) · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Advances of medical nanorobots for future cancer treatments.Journal of hematology & oncology · 2023
    Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaoxia SongDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Zhi ChenDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Xue ZhangDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Junfeng XiongDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Teng JiangDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Zihan WangDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Xinran GengDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
U Kei CheangDepartment of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China. cheanguk@sustech.edu.cn.
Southern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment.

Indexed as

Hyperthermia, InducedInfrared RaysMagneticsPhototherapyRoboticsAntineoplastic AgentsCell Line, TumorDoxorubicinDrug LiberationHumansAntineoplastic AgentsDoxorubicin

Identifiers

PMID33846437
PMCPMC8041914
OpenAlexW3154089339

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.