Evidence map›Paper›PMID 33846368›Full record

ArticleScientific reports2021

Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants.

Federica Laguzzi, Buamina Maitusong, Rona J Strawbridge, Damiano Baldassarre, Fabrizio Veglia, Steve E Humphries, Rainer Rauramaa, Sudhir Kurl, Andries J Smit, Philippe Giral and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 7 countries.

Federica LaguzziUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177, Stockholm, Sweden. federica.laguzzi@ki.se.
Buamina MaitusongUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177, Stockholm, Sweden.
Rona J StrawbridgeInstitute of Mental Health and Wellbeing, Mental Health and Wellbeing, University of Glasgow, Glasgow, UK.
Damiano BaldassarreDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy.
Fabrizio VegliaCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Steve E HumphriesCentre for Cardiovascular Genetics, Institute Cardiovascular Science, University College London, London, UK.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Sudhir KurlInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Andries J SmitDepartment of Medicine, University Medical Center Groningen, Groningen, The Netherlands.
Philippe GiralAssistance Publique-Hôpitaux de Paris, Service Endocrinologie-Métabolisme, Groupe Hospitalier Pitié-Salpétrière, Unités de Prévention Cardiovasculaire, Paris, France.
Angela SilveiraCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden.
Elena TremoliCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Anders HamstenCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden.
Ulf de FaireUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177, Stockholm, Sweden.
Bruna GiganteCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Karin LeanderUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177, Stockholm, Sweden.
IMPROVE Study group
Centro Cardiologico Monzino · ITKarolinska Institutet · SEUniversity of Eastern Finland · FIUniversity Medical Center Groningen · NLUniversity of Perugia · ITAssistance Publique – Hôpitaux de Paris · FRUniversity College London · GBAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITKarolinska University Hospital · SEKuopio University Hospital · FIUppsala University · SEUniversity of Milan · ITXinjiang Medical University · CN

Funding

Medical Research Council MR/S003061/1
6 · The paper itself

Abstract

The relationship between intake of saturated fats and subclinical atherosclerosis, as well as the possible influence of genetic variants, is poorly understood and investigated. We aimed to investigate this relationship, with a hypothesis that it would be positive, and to explore whether genetics may modulate it, using data from a European cohort including 3,407 participants aged 54-79 at high risk of cardiovascular disease. Subclinical atherosclerosis was assessed by carotid intima-media thickness (C-IMT), measured at baseline and after 30 months. Logistic regression (OR; 95% CI) was employed to assess the association between high intake of food rich in saturated fat (vs. low) and: (1) the mean and the maximum values of C-IMT in the whole carotid artery (C-IMT

Indexed as

AtherosclerosisCarotid Intima-Media ThicknessGenetic Predisposition to DiseaseAgedCohort StudiesDietary FatsFemaleHumansMaleMiddle AgedRisk FactorsDietary Fats

Identifiers

PMID33846368
PMCPMC8042105
OpenAlexW3155337999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.