ArticleScientific reports2021
Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Glioma region-specific metabolites associated with patient seizures.Journal of neuro-oncology · 2026Article
- New candidate gene mutations in astrocytoma with seizures.Scientific reports · 2025Article
- Optimized Long-TEJournal of magnetic resonance imaging : JMRI · 2025Article
- Asymmetric efficacy of VNS within a single patient with bilateral focal frontal lobe epilepsy: A case report.Acta neurochirurgica · 2025Article
- Elevated glioma-related cortical glutamateBrain communications · 2025Article
- Applied Fence-Post Techniques Using Deep Electrodes Instead of Catheters for Resection of Glioma Complicated with Frequent Epileptic Seizures: A Case Report.Brain sciences · 2023Article
- Metabolomics in High Grade Gliomas.RAS oncology & therapy · 2022Article
- Glutamate to GABA ratio is elevated in patients with IDH-mutant lower-grade gliomas and seizures.Neuro-oncology advancesArticle
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood. This study hypothesized that analyzing quantified metabolites using magnetic resonance spectroscopy (MRS) might provide novel insights to better understand the epileptogenesis in gliomas, and specific metabolites might be indicators of preoperative seizures in gliomas. We retrospectively investigated patient information (gender, age at diagnosis of tumor, their survival time) and tumor information (location, histology, genetic features, and metabolites according to MRS) in patients with gliomas. The data were correlated with the incidence of seizure and analyzed statistically. Of 146 adult supratentorial gliomas, isocitrate dehydrogenase (IDH) mutant tumors significantly indicated higher incidence of preoperative seizures than IDH wild-type gliomas. However, MRS study indicated that glutamate concentration in IDH wild-type gliomas was higher than that in IDH mutant gliomas. Glutamate was not associated with high frequency of preoperative seizures in patients with gliomas. Instead, increased total N-acetyl-L-aspartate (tNAA) was significantly associated with them. Moreover, multivariable analysis indicated that increased level of tNAA was an independent predictor of preoperative seizures. According to MRS analysis, tNAA, rather than glutamate, might be a useful to detect preoperative seizures in patient with supratentorial gliomas.
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