Evidence map›Paper›PMID 33846329›Full record

ArticleNature communications2021

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.

Pradeep Natarajan, Akhil Pampana, Sarah E Graham, Sanni E Ruotsalainen, James A Perry, Paul S de Vries, Jai G Broome, James P Pirruccello, Michael C Honigberg, Krishna Aragam and 93 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Gene-Environment Interactions for Cardiovascular Disease.Current atherosclerosis reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

103 authors at 20 institutions in 9 countries.

Pradeep NatarajanCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-8402-7435
Akhil PampanaCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4167-0540
Sarah E GrahamDepartment of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1271-2489
Sanni E RuotsalainenInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
James A PerryUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5050-2074
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jai G BroomeDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7638-0749
James P PirruccelloCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6088-4037
Michael C HonigbergCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Krishna AragamCardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Brooke WolfordDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3153-1552
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8509-148X
Lucinda Antonacci-FultonThe McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Moscati ArdenThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, USA.
Stella AslibekyanDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2349-0009
Christie M BallantyneSection of Cardiovascular Research, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6432-1730
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3443-8030
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Brian E CadeDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1424-0673
Ron DoThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3144-3627
Harsha DoddapaneniHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-2433-633X
Leslie S EmeryDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9070-9886
Yi-Jen HungDivision of Endocrine and Metabolism, Tri-Service General Hospital Songshan branch, Taipei, Taiwan.
Marguerite R IrvinDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Alyna T KhanDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Leslie LangeDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jiwon LeeDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4079-7494
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7038-1844
Lisa W MartinDivision of Cardiology, George Washington University School of Medicine and Healthcare Sciences, Washington, DC, USA.ORCID http://orcid.org/0000-0003-4352-0914
Ginger MetcalfHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
May E MontasserUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Baltimore, MD, USA.
Jee-Young MoonDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Donna MuznyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Jeffrey R O'ConnellUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Baltimore, MD, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-8883-2511
Juan M PeraltaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.ORCID http://orcid.org/0000-0002-8811-5579
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9717-8459
Adrienne M StilpDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Michael TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Fei Fei WangDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Daniel E WeeksDepartments of Human Genetics and Biostatistics, University of Pittsburgh, Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9410-7228
Lisa R YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7117-1075
James G WilsonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Goncalo AbecasisDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1509-1825
Donna K ArnettDeans office, School of Public Health, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0003-2219-657X
Lewis C BeckerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.ORCID http://orcid.org/0000-0001-6250-5723
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Yi-Cheng ChangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-8077-5011
Yii-Der I ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Won Jung ChoiPsomagen. Inc. (formerly Macrogen USA), Rockville, MD, USA.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.ORCID http://orcid.org/0000-0002-9501-600X
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Mark J DalyProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Susan K DutcherThe McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5689-5753
Patrick T EllinorProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2067-0533
Myriam FornageInstitute of Molecular Medicine, the University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Barry I FreedmanDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-, Salem, NC, USA.ORCID http://orcid.org/0000-0003-0275-5530
Stacey GabrielGenomics Platform, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Soren GermerNew York Genome Center, New York, NY, USA.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, and Tulane University Translational Science Institute, Tulane University, New Orleans, LA, USA.
Kristian HveemDepartment of Public Health and General Practice, HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway.
Gail P JarvikDepartments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6710-8708
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Eimear KennyThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, USA.
Ryan W KimPsomagen. Inc. (formerly Macrogen USA), Rockville, MD, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2572-4040
Seonwook LeePsomagen. Inc. (formerly Macrogen USA), Rockville, MD, USA.
Don M Lloyd-JonesPreventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Steven A LubitzCardiac Arrhythmia Service and Cardiovascular Research Center Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9599-4866
Rasika A MathiasDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Karine A Viaud MartinezIllumina Laboratory Services, Illumina inc., San Diego, CA, USA.
Stephen T McGarveyDepartment of Epidemiology and International Health Institute, Brown University, Providence, RI, USA.
Braxton D MitchellUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine, Baltimore, MD, USA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Aarno PalotieProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2527-5874
Cheol Joo ParkPsomagen. Inc. (formerly Macrogen USA), Rockville, MD, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
D C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Susan RedlineDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alexander P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Daekwan SeoPsomagen. Inc. (formerly Macrogen USA), Rockville, MD, USA.
Jeong-Sun SeoPsomagen. Inc. (formerly Macrogen USA), Rockville, MD, USA.
Albert V SmithDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1942-5845
Russell P TracyDepartments of Pathology & Laboratory Medicine and Biochemistry, Larrner College of Medicine, University of Vermont, Colchester, VT, USA.ORCID http://orcid.org/0000-0002-0080-2420
Ramachandran S VasanSections of Preventive Medicine and Epidemiology and Cardiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7357-5970
Sekar KathiresanProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6724-032X
L Adrienne CupplesNHLBI Framingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0003-0273-7965
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Samuli RipattiProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0504-1202
Cristen WillerDepartment of Internal Medicine: Cardiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5645-4966
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
FinnGen
Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA. gpeloso@bu.edu.ORCID http://orcid.org/0000-0002-5355-8636
University of Washington · USUniversity of Helsinki · FIUniversity of Maryland, Baltimore · USBroad Institute · USUniversity of Michigan · USBrigham and Women's Hospital · USPirkanmaa Hospital District · FIJohns Hopkins University · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USPfizer (United States) · USUniversity of Colorado Denver · USAbbVie (United States) · USFinnish Institute for Health and Welfare · FIGlaxoSmithKline (United Kingdom) · GBNorthern Ostrobothnia Hospital District · FINational Institutes of Health · USHospital District of Helsinki and Uusimaa · FIBiogen (United States) · USAstraZeneca (United Kingdom) · GBBorealis (Finland) · FI

Funding

Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RYAN, ALICE S. · 2005 to 2019
$17.3M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Using genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9M
Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
Phenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2M
Clonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9M
Clonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9M
Using Genetics to Inform Mechanism of Cardiovascular DiseaseR35HL135824 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLER, CRISTEN J · 2017 to 2022
$5.4M
NHGRI NIH HHS T32 HG000040NHLBI NIH HHS K01 HL125751NHLBI NIH HHS K01 HL135405NHLBI NIH HHS K08 HL140203NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R03 HL141439NHLBI NIH HHS R03 HL154284NHLBI NIH HHS R35 HL135818NHLBI NIH HHS R35 HL135824NHLBI NIH HHS T32 HL007208NHLBI NIH HHS T32 HL094301NIA NIH HHS K01 AG059898NIDDK NIH HHS P30 DK072488
6 · The paper itself

Abstract

Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10

Indexed as

Cardiometabolic Risk FactorsChromosomes, Human, XEye ProteinsFemaleGene Expression RegulationGenetic Association StudiesGenetic LociGenetic Predisposition to DiseaseGenotypeHumansLipidsMaleMiddle AgedNerve Tissue ProteinsPhenomicsPolymorphism, Single NucleotideCHRDL1 protein, humanEye ProteinsLipidsNerve Tissue Proteins

Identifiers

PMID33846329
PMCPMC8042019
OpenAlexW3153429005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.