Evidence map›Paper›PMID 33846325›Full record

ArticleNature communications2021

Regulation of Arabidopsis photoreceptor CRY2 by two distinct E3 ubiquitin ligases.

Yadi Chen, Xiaohua Hu, Siyuan Liu, Tiantian Su, Hsiaochi Huang, Huibo Ren, Zhensheng Gao, Xu Wang, Deshu Lin, James A Wohlschlegel and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. CUL3Science advances · 2026
    Article
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  6. Protein design accelerates the development and application of optogenetic tools.Computational and structural biotechnology journal · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Yadi Chen *College of Life Sciences, Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, China.
Xiaohua Hu *College of Life Sciences, Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, China.
Siyuan LiuCollege of Life Sciences, Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, China.
Tiantian SuDepartment of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA, USA.
Hsiaochi HuangDepartment of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA, USA.
Huibo RenCollege of Life Sciences, Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, China.
Zhensheng GaoCollege of Life Sciences, Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, China.
Xu WangCollege of Life Sciences, Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, China.
Deshu LinCollege of Life Sciences, Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, China.
James A WohlschlegelDepartment of Biological Chemistry, University of California, Los Angeles, CA, USA.ORCID 0000-0003-3399-901X
Qin WangCollege of Life Sciences, Basic Forestry and Proteomics Research Center, Fujian Agriculture and Forestry University, Fuzhou, China. qinwangCRY@163.com.ORCID 0000-0002-9202-8005
Chentao LinDepartment of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA, USA.ORCID 0000-0002-0004-8480
Fujian Agriculture and Forestry University · CNUniversity of California, Los Angeles · US

Funding

The signaling mechanisms of Arabidopsis CRY2R01GM056265 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIN, CHENTAO · 2001 to 2021
$9.5M
Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
PLANT PHOTOSENSORY RECEPTOR CRY2--SIGNALING MECHANISMR29GM056265 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIN, CHENTAO · 1997 to 2001
$204k
NIGMS NIH HHS R01 GM056265NIGMS NIH HHS R01 GM089778NIGMS NIH HHS R29 GM056265
6 · The paper itself

Abstract

Cryptochromes (CRYs) are photoreceptors or components of the molecular clock in various evolutionary lineages, and they are commonly regulated by polyubiquitination and proteolysis. Multiple E3 ubiquitin ligases regulate CRYs in animal models, and previous genetics study also suggest existence of multiple E3 ubiquitin ligases for plant CRYs. However, only one E3 ligase, Cul4

Indexed as

ArabidopsisArabidopsis ProteinsCryptochromesHEK293 CellsHumansLightModels, BiologicalMutationPhosphorylationPhotoreceptors, PlantPolyubiquitinProtein BindingProteolysisSeedlingsUbiquitinationUbiquitin-Protein LigasesArabidopsis ProteinsAT2G32950 protein, ArabidopsisCRY2 protein, ArabidopsisCryptochromesPhotoreceptors, PlantPolyubiquitinUbiquitin-Protein Ligases

Identifiers

PMID33846325
PMCPMC8042123
OpenAlexW3156524163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.