ArticleNature communications2021
Two-dimensional TIRF-SIM-traction force microscopy (2D TIRF-SIM-TFM).
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- T cells are blind to the dark mechanics of tumors.Trends open · 2026Review
- Traction Force Microscopy with DNA FluoroCubes.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Interface-Sensitive Epi-Coherent Anti-Stokes Raman Scattering Microscopy for Imaging Cell Adhesion Dynamics.Analytical chemistry · 2026Article
- Spatiotemporal dynamics of AHA2 reveal that RALF1 induces its endocytosis and vacuolar degradation.Plant communications · 2025Article
- A microfluidic rheometer for tumor mechanics and invasion studies.Lab on a chip · 2025Article
- Interface-Sensitive Epi-Coherent Anti-Stokes Raman Scattering Microscopy for Imaging Cell Adhesion Dynamics.bioRxiv : the preprint server for biology · 2025Article
- Engineered In Vitro Platforms for Mechanochemical Control of Cell Migration.Cold Spring Harbor perspectives in biology · 2025Review
- A microfluidic rheometer for tumor mechanics and invasion studies.bioRxiv : the preprint server for biology · 2025Article
- Mechanical force matters in early T cell activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- 3D Traction Force Microscopy in Biological Gels: From Single Cells to Multicellular Spheroids.Annual review of biomedical engineering · 2024Review
- Multimodal analysis of traction forces and the temperature dynamics of living cells with a diamond-embedded substrate.Biomedical optics express · 2024Article
- Molecular Force Sensors for Biological Application.International journal of molecular sciences · 2024Review
- Field Guide to Traction Force Microscopy.Cellular and molecular bioengineering · 2024Review
- Image restoration in frequency space using complex-valued CNNs.Frontiers in artificial intelligence · 2024Article
- Bayesian traction force estimation using cell boundary-dependent force priors.Biophysical journal · 2023Article
- Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review.Biomaterials research · 2023Review
- Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication.Journal of pharmaceutical analysis · 2023Article
- Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Quantifying Immune Cell Force Generation Using Traction Force Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Quantifying small, rapidly evolving forces generated by cells is a major challenge for the understanding of biomechanics and mechanobiology in health and disease. Traction force microscopy remains one of the most broadly applied force probing technologies but typically restricts itself to slow events over seconds and micron-scale displacements. Here, we improve >2-fold spatially and >10-fold temporally the resolution of planar cellular force probing compared to its related conventional modalities by combining fast two-dimensional total internal reflection fluorescence super-resolution structured illumination microscopy and traction force microscopy. This live-cell 2D TIRF-SIM-TFM methodology offers a combination of spatio-temporal resolution enhancement relevant to forces on the nano- and sub-second scales, opening up new aspects of mechanobiology to analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.