Evidence map›Paper›PMID 33846262›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Decoding allosteric regulation by the acyl carrier protein.

Terra Sztain, Thomas G Bartholow, D John Lee, Lorenzo Casalino, Andrew Mitchell, Megan A Young, Jianing Wang, J Andrew McCammon, Michael D Burkart

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Design and engineering of allosteric communications in proteins.Current opinion in structural biology · 2022
    Review
  16. A GXThe Journal of biological chemistry · 2021
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Terra SztainDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0358.ORCID 0000-0002-1327-8541
Thomas G BartholowDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0358.
D John LeeDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0358.ORCID 0000-0002-5132-3243
Lorenzo CasalinoDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0358.ORCID 0000-0003-3581-1148
Andrew MitchellDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0358.ORCID 0000-0003-0501-392X
Megan A YoungDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0358.
Jianing WangDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0358.ORCID 0000-0003-0135-8832
J Andrew McCammonDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0358; jmccammon@ucsd.edu mburkart@ucsd.edu.ORCID 0000-0003-3065-1456
Michael D BurkartDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0358; jmccammon@ucsd.edu mburkart@ucsd.edu.ORCID 0000-0002-4472-2254

Funding

THEORY OF BIOMOLECULAR DIFFUSIONR01GM031749 · NIGMS · UNIVERSITY OF HOUSTON · PI HUBER, GARY ALEXANDER, MCCAMMON, JAMES ANDREW · 1985 to 2022
$7.8M
Protein-Protein Interactions in Natural Product BiosynthesisR01GM095970 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D. · 2012 to 2025
$5.9M
Chemistry-Biology Interfaces at UCSDT32GM146648 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael D. Burkart, Alexis C. Komor · 2022 to 2026
$876k
NIGMS NIH HHS R01 GM031749NIGMS NIH HHS R01 GM095970NIGMS NIH HHS T32 GM146648
6 · The paper itself

Abstract

Enzymes in multistep metabolic pathways utilize an array of regulatory mechanisms to maintain a delicate homeostasis [K. Magnuson, S. Jackowski, C. O. Rock, J. E. Cronan, Jr,

Indexed as

Acyl Carrier ProteinAllosteric RegulationAmino Acid SequenceEscherichia coliEscherichia coli ProteinsMagnetic Resonance SpectroscopyMolecular Docking SimulationMolecular Dynamics SimulationProtein ConformationProtein Interaction Domains and MotifsProtein Interaction MapsAcyl Carrier ProteinEscherichia coli Proteinsacyl carrier proteinchain flippingmolecular dynamicsnuclear magnetic resonance

Identifiers

PMID33846262
PMCPMC8072227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.