Evidence map›Paper›PMID 33846151›Full record

ArticleBMJ open2021

Compression hosiery to avoid post-thrombotic syndrome (CHAPS) protocol for a randomised controlled trial (ISRCTN73041168).

Ankur Thapar, Rebecca Lawton, Laura Burgess, Joseph Shalhoub, Andrew Bradbury, Nicky Cullum, David Epstein, Manjit Gohel, Robert Horne, Beverley J Hunt and 2 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Compression Hosiery to Avoid the Post-Thrombotic Syndrome: a synopsis of the CHAPS RCT.Health technology assessment (Winchester, England) · 2025
    Trial
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Ankur ThaparAcademic Section of Vascular Surgery, Imperial College London, London, UK a.thapar09@imperial.ac.uk.ORCID 0000-0003-4542-1100
Rebecca LawtonAcademic Section of Vascular Surgery, Imperial College London, London, UK.
Laura BurgessAcademic Section of Vascular Surgery, Imperial College London, London, UK.
Joseph ShalhoubAcademic Section of Vascular Surgery, Imperial College London, London, UK.
Andrew BradburyInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
Nicky CullumSchool of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK.
David EpsteinFaculty of Economic and Business Sciences, University of Granada, Granada, Andalucía, Spain.
Manjit GohelDepartment of Vascular Surgery, Addenbrooke's Hospital, Cambridge, Cambridgeshire, UK.
Robert HorneSchool of Pharmacy, University College London, London, London, UK.
Beverley J HuntDepartment of Haematology, Guy's & St Thomas' Foundation Trust, London, UK.
John NorrieEdinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK.
A H DaviesAcademic Section of Vascular Surgery, Imperial College London, London, UK.
Imperial College London · GBAddenbrooke's Hospital · GBCardiovascular Institute Hospital · JPGuy's and St Thomas' NHS Foundation Trust · GBMid Essex Hospital Services NHS Trust · GBUniversidad de Granada · ESUniversity College London · GBUniversity of Edinburgh · GBUniversity of Manchester · GB

Funding

Chief Scientist Office
6 · The paper itself

Abstract

introductionUp to 50% of patients develop post-thrombotic syndrome (PTS) after an above knee deep vein thrombosis (DVT). The aim of the study was to determine the effect of graduated compression stockings in preventing PTS after DVT. METHODS AND ANALYSIS: Pragmatic, UK multicentre randomised trial in adults with first above knee DVT. The standard of care arm is anticoagulation. The intervention arm will receive anticoagulation plus stockings (European class II, 23-32 mm Hg compression) worn for a median of 18 months. The primary endpoint is PTS using the Villalta score. Analysis of this will be through a time to event approach and cumulative incidence at median 6, 12 and 18 months. An ongoing process evaluation will examine factors contributing to adherence to stockings to understand if and how the behavioural interventions were effective. ETHICS AND DISSEMINATION: UK research ethics committee approval (reference 19/LO/1585). Dissemination though the charity Thrombosis UK, the Imperial College London website, peer-reviewed publications and international conferences. TRIAL REGISTRATION NUMBER: ISRCTN registration number 73041168.

Indexed as

Postthrombotic SyndromeVenous ThrombosisAdultHumansIncidenceLondonPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicStockings, Compressionanticoagulationthromboembolismvascular medicine

Identifiers

PMID33846151
PMCPMC8048019
OpenAlexW3156193695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.