ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2021
Survival implications of prescription opioid and benzodiazepine use in lung transplant recipients: Analysis of linked transplant registry and pharmacy fill records.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Impact of Preoperative Opioid Use in Lung Transplant Recipients: A Retrospective Study.Cureus · 2025Article
- Assessment of postoperative outcomes of prescription benzodiazepine use in lung transplant recipients.Journal of thoracic disease · 2025Article
- Association of Pre-Lung Transplant Opioid Use With Posttransplant Opioid Use and Outcomes.Annals of thoracic surgery short reports · 2025Article
- Intercostal nerve cryoablation in lung transplantation: A single-center, propensity score-matched analysis.JTCVS open · 2025Article
- Chronic Postsurgical Pain Following Lung Transplantation: Characteristics, Risk Factors, Treatment, and Prevention: A Narrative Review.Pain and therapy · 2024Review
- Intercostal nerve cryoablation as part of an opioid-sparing protocol reduces opioid and epidural use after lung transplant.JHLT open · 2024Article
- Posttransplant Diabetes Mellitus and Immunosuppression Selection in Older and Obese Kidney Recipients.Kidney medicine · 2022Article
- A Cascade of Structural Barriers Contributing to Racial Kidney Transplant Inequities.Advances in chronic kidney disease · 2021Review
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 3 countries.
Funding
Abstract
backgroundPrescription opioid and benzodiazepine use have been associated with morbidity and mortality among some groups of solid organ transplant recipients, but implications for outcomes among lung transplant patients are not well described.
methodsWe conducted a retrospective cohort study using linked national transplant registry and pharmaceutical records to characterize the associations between benzodiazepine and opioid prescription fills in the years before and after lung transplant (2006-2017), with risk-adjusted posttransplant survival (adjusted hazard ratio,
resultsAmong 11,568 recipients, 33.7% filled an opioid prescription, and 25.8% filled a benzodiazepine prescription before transplant. Compared to patients without prescriptions, those who filled both short- and long-acting benzodiazepine prescriptions before transplant had 2-fold higher mortality in the first year posttransplant (aHR,
conclusionsBenzodiazepine prescription fills before and after lung transplant, and opioid fills after transplant, are independently associated with posttransplant mortality. Review of benzodiazepine and opioid use history is relevant to risk-stratifying patients before and after lung transplant.
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