ReviewGenes and environment : the official journal of the Japanese Environmental Mutagen Society2021
Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach.
Review in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Occupational hazard exposures among archivists.Frontiers in public health · 2025Pooled it
- An AI assistant for critically assessing and synthesizing clusters of journal articles.Global epidemiology · 2025Article
- Assessment of physicochemical properties and biological responses of chemically surface-modified microcapsules for self-healing dental restorative materials.Materials & design · 2025Article
- Transgenerational Reproductive and Developmental Toxicity Induced by N-Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster.Journal of applied toxicology : JAT · 2025Article
- Engineered nanofiber scaffolds prime chromatin reorganization to sensitize cells for long-term and low-dose chemical hazard detection.Frontiers in pharmacology · 2025Article
- Toxicity of formaldehyde, and its role in the formation of harmful and aromatic compounds during food processing.Food chemistry: X · 2025Review
- Landscape analysis of environmental data sources for linkage with SEER cancer patients database.Journal of the National Cancer Institute. Monographs · 2024Article
- Fabrication and Characterization of an Electrochemical Platform for Formaldehyde Oxidation, Based on Glassy Carbon Modified with Multi-Walled Carbon Nanotubes and Electrochemically Generated Palladium Nanoparticles.Materials (Basel, Switzerland) · 2024Article
- Recent Advances in Electrochemical Sensors for Formaldehyde.Molecules (Basel, Switzerland) · 2024Review
- Genetic prediction of causal association between serum bilirubin and hematologic malignancies: a two-sample Mendelian randomized and bioinformatics study.Frontiers in oncology · 2024Article
- Comprehensive interventions to reduce occupational hazards among medical staff in the pathology department of five primary hospitals.BMC public health · 2023Article
- Aldehyde-Associated Mutagenesis─Current State of Knowledge.Chemical research in toxicology · 2023Review
- Highly Sensitive and Selective Formaldehyde Gas Sensors Based on Polyvinylpyrrolidone/Nitrogen-Doped Double-Walled Carbon Nanotubes.Sensors (Basel, Switzerland) · 2022Article
- A disaster victim identification workshop focused on forensic odontology using embalmed human remains.International journal of legal medicine · 2022Article
- Network-based integrated analysis for toxic effects of high-concentration formaldehyde inhalation exposure through the toxicogenomic approach.Scientific reports · 2022Article
- The formation of SCEs as an effect of occupational exposure to formaldehyde.Archives of toxicology · 2022Article
- Review
- Indoor air quality improvement and purification by atmospheric pressure Non-Thermal Plasma (NTP).Scientific reports · 2021Article
- Occupational Exposure to Formaldehyde and Cancer Risk Assessment in an Anatomy Laboratory.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Formaldehyde is a widely used but highly reactive and toxic chemical. The International Agency for Research on Cancer classifies formaldehyde as a Group 1 carcinogen, based on nasopharyngeal cancer and leukemia studies. However, the correlation between formaldehyde exposure and leukemia incidence is a controversial issue. To understand the association between formaldehyde exposure and leukemia, we explored biological networks based on formaldehyde-related genes retrieved from public and commercial databases. Through the literature-based network approach, we summarized qualitative associations between formaldehyde exposure and leukemia. Our results indicate that oxidative stress-mediated genetic changes induced by formaldehyde could disturb the hematopoietic system, possibly leading to leukemia. Furthermore, we suggested major genes that are thought to be affected by formaldehyde exposure and associated with leukemia development. Our suggestions can be used to complement experimental data for understanding and identifying the leukemogenic mechanism of formaldehyde.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.