ArticleParasites & vectors2021
Apoptosis-like cell death upon kinetoplastid induction by compounds isolated from the brown algae Dictyota spiralis.
Article in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Marine Natural Products as Novel Treatments for Parasitic Diseases.Handbook of experimental pharmacology · 2025Review
- Anti-COVID Drugs (MMV COVID Box) as Leishmanicidal Agents: Unveiling New Therapeutic Horizons.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Meroterpenoids fromPharmaceuticals (Basel, Switzerland) · 2023Article
- The Biodiversity of the GenusMolecules (Basel, Switzerland) · 2022Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe in vitro activity of the brown seaweed Dictyota spiralis against both Leishmania amazonensis and Trypanosoma cruzi was evaluated in a previous study. Processing by bio-guided fractionation resulted in the isolation of three active compounds, classified as diterpenes. In the present study, we performed several assays to detect clinical features associated to cell death in L. amazonensis and T. cruzi with the aim to elucidate the mechanism of action of these compounds on parasitic cells.
methodsThe aims of the experiments were to detect and evaluate specific events involved in apoptosis-like cell death in the kinetoplastid, including DNA condensation, accumulation of reactive oxygen species and changes in ATP concentration, cell permeability and mitochondrial membrane potential, respectively, in treated cells.
resultsThe results demonstrated that the three isolated diterpenes could inhibit the tested parasites by inducing an apoptosis-like cell death.
conclusionsThese results encourage further investigation on the isolated compounds as potential drug candidates against both L. amazonensis and T. cruzi.
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