Evidence map›Paper›PMID 33845643›Full record

ReviewCell transplantation

Recent Findings on Cell-Based Therapies for COVID19-Related Pulmonary Fibrosis.

Hong-Meng Chuang, Li-Ing Ho, Horng-Jyh Harn, Ching-Ann Liu

Open access · goldAbstract readReview
In one paragraph

Review in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Hong-Meng ChuangLaboratory of Translational Medicine Office, Development Center for Biotechnology, Taipei.ORCID 0000-0003-1978-3618
Li-Ing HoDivision of Respiratory Therapy, Department of Chest Medicine, Taipei Veterans General Hospital, Taipei.
Horng-Jyh HarnBioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien.ORCID 0000-0001-6777-3284
Ching-Ann LiuBioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien.ORCID 0000-0002-0392-7069
Development Center for Biotechnology · TWTaipei Veterans General Hospital · TWTzu Chi Foundation · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 has spread worldwide, including the United States, United Kingdom, and Italy, along with its site of origin in China, since 2020. The virus was first found in the Wuhan seafood market at the end of 2019, with a controversial source. The clinical symptoms of COVID-19 include fever, cough, and respiratory tract inflammation, with some severe patients developing an acute and chronic lung injury, such as acute respiratory distress syndrome (ARDS) and pulmonary fibrosis (PF). It has already claimed approximately 300 thousand human lives and the number is still on the rise; the only way to prevent the infection is to be safe till vaccines and reliable treatments develop. In previous studies, the use of mesenchymal stem cells (MSCs) in clinical trials had been proven to be effective in immune modulation and tissue repair promotion; however, their efficacy in treating COVID-19 remains underestimated. Here, we report the findings from past experiences of SARS and MSCs, and how SARS could also induce PF. Such studies may help to understand the rationale for the recent cell-based therapies for COVID-19.

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsCoronavirusCOVID-19HumansPulmonary FibrosisRenin-Angiotensin SystemSARS-CoV-2Severe Acute Respiratory SyndromeTransforming Growth Factor betaTransforming Growth Factor betaCOVID-19pulmonary fibrosis

Identifiers

PMID33845643
PMCPMC8047934
OpenAlexW3156198738

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.