Evidence map›Paper›PMID 33845605›Full record

SynthesisThe Journal of international medical research2021

Forkhead box F2 as a novel prognostic biomarker and potential therapeutic target in human cancers prone to bone metastasis: a meta-analysis.

Qing Chen, Lei Zhou, Fancheng Chen, Annan Hu, Ketao Wang, Haifeng Liang, Jian Dong

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qing ChenDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Lei ZhouDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Fancheng ChenDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Annan HuDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Ketao WangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Haifeng LiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jian DongDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-3978-4717
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo undertake a systematic review and meta-analysis to evaluate the prognostic value of Forkhead box F2 (FOXF2) levels in different types of cancers prone to bone metastasis.

methodsA systematic search of publications listed in electronic databases (The Web of Science, EMBASE®, PubMed®, PMC, Science Direct and CNKI) from inception to 5 November 2020 was conducted. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to assess the relationship between FOXF2 levels and patient prognosis including overall survival (OS) and disease-free survival (DFS).

resultsSixteen studies enrolling 8461 participants were included in the meta-analysis. High levels of FOXF2 were a predictor of OS (HR: 0.66; 95% CI 0.51, 0.86) and DFS (HR: 0.60; 95% CI 0.48, 0.76). The trim-and-fill analysis, sensitivity analysis and subgroup analyses stratified by the study characteristics confirmed the robustness of the results.

conclusionThese current findings indicate that high FOXF2 levels could be an indicator of a good prognosis in cancer patients with tumours that are prone to bone metastasis. FOXF2 levels might be a clinically important prognostic biomarker.

Indexed as

Bone NeoplasmsNeoplasmsBiomarkersDisease-Free SurvivalForkhead Transcription FactorsHumansPrognosisProportional Hazards ModelsBiomarkersForkhead Transcription FactorsFOXF2 protein, humanbone metastasisForkhead box F2meta-analysisprognosissurvivalsystematic review

Identifiers

PMID33845605
PMCPMC8047092
OpenAlexW3153022799

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.