ArticleNature2021
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 438 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
438citing papers in PubMed, 2 pooled it
41.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
438 citing papers in PubMed, 2 syntheses or guidelines pooled it, 718 citations in OpenAlex.
- Comprehensive proteomics and meta-analysis of COVID-19 host response.Nature communications · 2023Pooled it
- Identifying and profiling structural similarities between Spike of SARS-CoV-2 and other viral or host proteins with Machaon.Communications biology · 2023Pooled it
- Article
- Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis.Cell discovery · 2026Article
- Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a.EMBO reports · 2026Article
- Comparative proteomics of human naso-oropharyngeal swabs from COVID19 patients for identification of potential biomarker candidates.Biochemistry and biophysics reports · 2026Article
- PhoSARte: identification of SARS-CoV-2 phosphorylation sites using contrastive learning and protein language models.Briefings in bioinformatics · 2026Article
- A P3' methionine-to-phenylalanine substitution in the NSP6-7 substrate peptide alters SARS-CoV-2 MThe Journal of biological chemistry · 2026Article
- Article
- Article
- Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function.Microbiology spectrum · 2026Article
- SARS-CoV-2 ORF3a suppresses host antiviral interferon responses by promoting STUB1-mediated PTEN proteasomal degradation.Journal of virology · 2026Article
- Exploring Key Regulators of Mitochondrial Dynamics and Immune Response in SARS-CoV-2 Infection.Viruses · 2026Article
- O-GlcNAcylation licenses RNF166 to degrade the M protein of porcine coronaviruses.PLoS pathogens · 2026Article
- An engineered viral RNA degrader on mitochondrial surface that mitigates RNA virus infection.Nature communications · 2026Article
- The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes.Nature communications · 2026Article
- MELK inhibition disrupts actin cytoskeleton and broadly restricts human coronavirus infections.Nature communications · 2026Article
- Multilabel prediction of virus target proteins via multimodal graph representation learning.PLoS computational biology · 2026Article
- Leveraging ADMET Profiling, Network Pharmacology, and Molecular Docking to Evaluate the Repurposing of Product Nkabinde for COVID-19 Treatment.Biomedicines · 2026Article
378 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 8 institutions in 2 countries.
Alexey Stukalov *Technical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.
Virginie Girault *Technical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0002-3240-4400
Vincent Grass *Technical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0001-7710-4789
Ozge Karayel *Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany.ORCID http://orcid.org/0000-0003-2541-1159
Valter Bergant *Technical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0003-3458-9506
Christian Urban *Technical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0002-4080-2468
Darya A Haas *Technical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0001-5543-4875
Yiqi Huang *Technical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0001-7256-8699
Lila OubrahamTechnical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0002-9991-5336
Anqi WangTechnical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.
M Sabri HamadTechnical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.
Antonio PirasTechnical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.
Fynn M HansenDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany.
Maria C TanzerDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany.
Igor ParonDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany.
Luca ZinzulaDepartment of Molecular Structural Biology, Max-Planck Institute of Biochemistry, Martinsried, Germany.ORCID http://orcid.org/0000-0001-6489-7070
Thomas EngleitnerInstitute of Molecular Oncology and Functional Genomics and Department of Medicine II, School of Medicine, Technical University of Munich, Munich, Germany.
Maria ReineckeChair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
Teresa M LavaccaTechnical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0002-0851-524X
Rosina EhmannBundeswehr Institute of Microbiology, Munich, Germany.
Roman WölfelBundeswehr Institute of Microbiology, Munich, Germany.
Jörg JoresInstitute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-3790-5746
Bernhard KusterChair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0002-9094-1677
Ulrike ProtzerTechnical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0002-9421-1911
Roland RadInstitute of Molecular Oncology and Functional Genomics and Department of Medicine II, School of Medicine, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-6849-9659
John ZiebuhrJustus Liebig University Giessen, Institute of Medical Virology, Giessen, Germany.ORCID http://orcid.org/0000-0002-5741-8825
Volker ThielInstitute of Virology and Immunology (IVI), Bern, Switzerland.ORCID http://orcid.org/0000-0002-5783-0887
Pietro ScaturroTechnical University of Munich, School of Medicine, Institute of Virology, Munich, Germany.ORCID http://orcid.org/0000-0001-9098-3087
Matthias MannDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany.ORCID http://orcid.org/0000-0003-1292-4799
Andreas PichlmairTechnical University of Munich, School of Medicine, Institute of Virology, Munich, Germany. andreas.pichlmair@tum.de.ORCID http://orcid.org/0000-0002-0166-1367
Technical University of Munich · DEMax Planck Institute of Biochemistry · DEGerman Cancer Research Center · DEGerman Center for Infection Research · DEUniversität der Bundeswehr München · DEUniversity of Bern · CHJustus-Liebig-Universität Gießen · DELeibniz Institute of Virology (LIV) · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-depth understanding of molecular functions of viral proteins and their interactions with the host proteome. Several individual omics studies have extended our knowledge of COVID-19 pathophysiology
Indexed as
Host-Pathogen InteractionsProteomicsAnimalsAntiviral AgentsAutophagyCell LineCOVID-19Datasets as TopicDrug Evaluation, PreclinicalHumansMatrix Metalloproteinase InhibitorsPhosphorylationProtein Interaction MapsProtein Kinase InhibitorsProtein Processing, Post-TranslationalProteomeAntiviral AgentsMatrix Metalloproteinase InhibitorsORF3a protein, SARS-CoV-2ORF8 protein, SARS-CoV-2Protein Kinase InhibitorsProteomeTransforming Growth Factor betaViral ProteinsViroporin Proteins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.