ArticleJournal of critical care2021
Cardio-pulmonary-renal interactions in ICU patients. Role of mechanical ventilation, venous congestion and perfusion deficit on worsening of renal function: Insights from the MIMIC-III database.
Article in Journal of critical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Mechanical ventilation-associated AKI: toward a multimodal and kidney-protective ventilatory framework.Intensive care medicine experimental · 2026Review
- Renal congestion syndrome in critically ill patients: a neglected mechanism of acute kidney injury - A narrative review.Annals of intensive care · 2026Review
- Venous congestion from a vascular waterfall perspective: reframing congestion as a dynamic Starling resistor phenomenon.Intensive care medicine experimental · 2025Review
- Ventilation-induced acute kidney injury in acute respiratory failure: Do PEEP levels matter?Critical care (London, England) · 2025Review
- Venous excess ultrasound score association with acute kidney injury in critically ill patients: a systematic review and meta-analysis of observational studies.The ultrasound journal · 2025Review
- Efficacy and validation of a clinical model to predict acute kidney injury in severe pneumonia requiring mechanical ventilation in elderly patients: a multicenter retrospective observational analysis.Frontiers in medicine · 2025Article
- Comment on: Association between intrarenal venous flow from Doppler ultrasonography and acute kidney injury in patients with sepsis in critical care: a prospective, exploratory observational study.Critical care (London, England) · 2023Article
- Relationship between positive end-expiratory pressure levels, central venous pressure, systemic inflammation and acute renal failure in critically ill ventilated COVID-19 patients: a monocenter retrospective study in France.Acute and critical care · 2023Article
- Article
- Risk Factors of AKI in Acute Respiratory Distress Syndrome: A Time-Dependent Competing Risk Analysis on Severe COVID-19 Patients.Canadian journal of kidney health and disease · 2023Article
- Central venous pressure and acute kidney injury in critically ill patients with multiple comorbidities: a large retrospective cohort study.BMC nephrology · 2022Observational
- Review
- Machine learning for early discrimination between transient and persistent acute kidney injury in critically ill patients with sepsis.Scientific reports · 2021Article
- Haemodynamic predisposition to acute kidney injury: Shadow and light!Journal of anaesthesiology, clinical pharmacologyReview
Corrections and comments
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Authors and funding
7 authors at 7 institutions in 3 countries.
Funding
Abstract
Background Mechanical ventilation (MV) in ICU patients may impact hemodynamics and renal function. We aimed to describe the interactions of MV settings, hemodynamic parameters and worsening of renal function (WRF). Methods We included adult patients admitted for the first time in the ICU from the MIMIC-III database. Mean arterial blood pressure (mABP), central venous pressure (CVP) and positive end-expiratory pressure (PEEP) were collected and summarized as a time-weighted mean. The main outcome was WRF defined as acute kidney injury (AKI) occurrence or one-KDIGO stage worsening compared to the KDIGO stage the day before. We used a multinomial logistic regression at day 1 (ldmk-1) and day 2 (ldmk-2) according to a landmark-approach, with a two-days sliding perspective. Results 27,248/61,051 patients met the inclusion criteria (15,258 male (56.0%); 60.1% over 60 y). ICU and hospital mortality were 7.4 and 10.7%, respectively. MV was independently associated with WRF in the ldmrk-1 and -2 models (relative risk ratio [RRR] 8.15 [6.58;10.11] and 7.08 [3.97;12.61] at day-3 and 4, respectively). In MV patients, PEEP was associated with WRF in the ldmrk-1 and -2 models (RRR 1.36 [1.16, 1.6] and 1.17 [0.88, 1.56] by 1 cmH
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