Evidence map›Paper›PMID 33845357›Full record

ArticleJournal of biomechanics2021

Influence of shear rate and surface chemistry on thrombus formation in micro-crevice.

Mansur Zhussupbekov, Wei-Tao Wu, Megan A Jamiolkowski, Mehrdad Massoudi, James F Antaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mansur ZhussupbekovMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Wei-Tao WuSchool of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing, China.
Megan A JamiolkowskiU.S. Food and Drug Administration (FDA), Center for Devices and Radiological Health (CDRH), Office of Science and Engineering Laboratories (OSEL), Silver Spring, Maryland, USA.
Mehrdad MassoudiU.S. Department of Energy, National Energy Technology Laboratory (NETL), Pittsburgh, PA, USA.
James F AntakiMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. Electronic address: antaki@cornell.edu.

Funding

Multiscale Model of Thrombosis in Artificial CirculationR01HL089456 · NHLBI · CORNELL UNIVERSITY · PI ANTAKI, JAMES F., BUTCHER, JONATHAN TALBOT · 2009 to 2024
$8.5M
NHLBI NIH HHS R01 HL089456
6 · The paper itself

Abstract

Thromboembolic complications remain a central issue in management of patients on mechanical circulatory support. Despite the best practices employed in design and manufacturing of modern ventricular assist devices, complexity and modular nature of these systems often introduces internal steps and crevices in the flow path which can serve as nidus for thrombus formation. Thrombotic potential is influenced by multiple factors including the characteristics of the flow and surface chemistry of the biomaterial. This study explored these elements in the setting of blood flow over a micro-crevice using a multi-constituent numerical model of thrombosis. The simulations reproduced the platelet deposition patterns observed experimentally and elucidated the role of flow, shear rate, and surface chemistry in shaping the deposition. The results offer insights for design and operation of blood-contacting devices.

Indexed as

Heart-Assist DevicesThromboembolismThrombosisBlood PlateletsHemodynamicsHumansStress, MechanicalBiomaterialsBlood flowCreviceNumerical modelingPlatelet depositionShear cleaningThrombosis

Identifiers

PMID33845357
PMCPMC8594740

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.