Evidence map›Paper›PMID 33845073›Full record

ArticleNeuropharmacology2021

Gabapentin attenuates somatic signs of precipitated THC withdrawal in mice.

M L Eckard, S G Kinsey

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Differential disruption of response alternation by precipitated ΔPharmacology, biochemistry, and behavior · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

M L EckardDepartment of Environmental Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA; Department of Psychology, West Virginia University, Morgantown, WV, USA.
S G KinseyDepartment of Psychology, West Virginia University, Morgantown, WV, USA; School of Nursing, University of Connecticut, Storrs, CT, USA. Electronic address: steven.kinsey@uconn.edu.
West Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Reagan Curtis · 2012 to 2026
$81.0M
Research Training Program in Behavioral and Biomedical SciencesT32GM132494 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Anne Courtney DeVries, Kevin T Larkin · 2019 to 2026
$2.8M
Reducing the deleterious effects of synthetic cannabinoid withdrawal on emotionality and motivationR03DA039335 · NIDA · WEST VIRGINIA UNIVERSITY · PI KINSEY, STEVEN G. · 2018 to 2019
$150k
NIDA NIH HHS R03 DA039335NIGMS NIH HHS T32 GM132494NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Cannabis is the most frequently used federally illicit substance in the United States. However, there are currently no FDA-approved pharmacotherapies to mitigate the withdrawal symptoms associated with cessation in heavy users. A promising, readily available, non-cannabinoid therapy are the gabapentinoids. Although currently approved for epilepsy and neuropathic pain, gabapentinoids are increasingly used for their "off-label" efficacy in treating various psychiatric conditions and substance abuse. Gabapentin (GBP) synergizes with cannabinoid agonism in neuropathic pain models, substitutes for Δ

Indexed as

AnimalsBehavior, AnimalCannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsCorticosteroneDronabinolGabapentinLocomotionMarijuana AbuseMiceRimonabantSubstance Withdrawal SyndromeTremorCannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsCorticosteroneDronabinolGabapentinRimonabantCannabis addictionCannabis use disorderDrug dependenceSubstance use disorders

Identifiers

PMID33845073
PMCPMC8204917
OpenAlexW3153418741

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.