ArticleAmerican journal of ophthalmology2021
Classification Criteria For Multiple Evanescent White Dot Syndrome.
Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review of Postvaccination Ocular Adverse Events: A Comprehensive Analysis of Published Reports.Journal of medical virology · 2025Pooled it
- To treat or not to treat: The clue lies in multimodal imaging.Indian journal of ophthalmology · 2026Article
- MEWDS-like Presentation Unmasking Sequential Bilateral Multifocal Choroiditis: Insights from Longitudinal Multimodal Imaging.Biomedicines · 2026Article
- Infectious eye disease in the 21st century-an overview.Eye (London, England) · 2024Review
- Increased incidence and diverse manifestations of multiple evanescent white dot syndrome during the COVID-19 pandemic.Scientific reports · 2024Article
- Comparison of clinical findings and subjective symptoms in a case of multiple evanescent white dot syndrome (MEWDS): A case report from a patient's perspective.Journal of general and family medicine · 2024Article
- Atypical multiple evanescent white dot syndrome presenting with peripheral retinal lesions.BMJ case reports · 2024Article
- Photoreceptor Integrity in MEWDS: Longitudinal Structure-Function Correlations.Investigative ophthalmology & visual science · 2024Observational
- Artificial Intelligence in Uveitis: Innovations in Diagnosis and Therapeutic Strategies.Clinical ophthalmology (Auckland, N.Z.) · 2024Review
- Clinical features and possible pathogenesis of multiple evanescent white dot syndrome with different retinal diseases and events: a narrative review.International journal of ophthalmology · 2024Review
- EOG and the En-Face Inner Segment/Outer Segment-Ellipsoid Complex Image in Multiple Evanescent White Dot Syndrome.International medical case reports journal · 2024Article
- Ocular Inflammation Post-Vaccination.Vaccines · 2023Review
- The role of a multicentre data repository in ocular inflammation: The Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS).Eye (London, England) · 2023Review
- Unilateral Multiple Evanescent White Dot Syndrome-Like Reaction Following the CyberKnife Stereotactic Radiotherapy for Choroidal Malignant Melanoma.Turkish journal of ophthalmology · 2023Article
- The standardisation of uveitis nomenclature (SUN) project.Clinical & experimental ophthalmology · 2022Review
- Multiple Evanescent White Dot Syndrome following BioNTech SARS-CoV2 mRNA vaccination.Journal francais d'ophtalmologie · 2022Article
- Article
- Multiple evanescent white dot syndrome (MEWDS): update on practical appraisal, diagnosis and clinicopathology; a review and an alternative comprehensive perspective.Journal of ophthalmic inflammation and infection · 2021Review
- [Development of classification criteria for uveitis by the standardization of uveitis nomenclature (SUN) working group].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Review
- Development of Classification Criteria for the Uveitides.American journal of ophthalmology · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
purposeThe purpose of this study was to determine classification criteria for multiple evanescent white dot syndrome (MEWDS).
designMachine learning of cases with MEWDS and 8 other posterior uveitides.
methodsCases of posterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on diagnosis using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used in the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the infectious posterior, or panuveitides. The resulting criteria were evaluated in the validation set.
resultsA total of 1,068 cases of posterior uveitides, including 51 cases of MEWDS, were evaluated by machine learning. Key criteria for MEWDS included: 1) multifocal gray-white chorioretinal spots with foveal granularity; 2) characteristic imaging on fluorescein angiography ("wreath-like" hyperfluorescent lesions) and/or optical coherence tomography (hyper-reflective lesions extending from retinal pigment epithelium through ellipsoid zone into the retinal outer nuclear layer); and 3) absent to mild anterior chamber and vitreous inflammation. Overall accuracy for posterior uveitides was 93.9% in the training set and 98.0% (95% confidence interval: 94.3-99.3) in the validation set. Misclassification rates for MEWDS were 7% in the training set and 0% in the validation set.
conclusionsThe criteria for MEWDS had a low misclassification rate and appeared to perform sufficiently well for use in clinical and translational research.
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