ArticleAmerican journal of ophthalmology2021
Classification Criteria for Cytomegalovirus Retinitis.
Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07679412 (An Exploratory Clinical Study of Autologous LB-DTK-CMV in Patients With Antiviral-Resistant and Refractory Cytomegalovirus Retinitis.), which is not on this map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Exploratory Clinical Study of Autologous LB-DTK-CMV in Patients With Antiviral-Resistant and Refractory Cytomegalovirus Retinitis.
Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Cytomegalovirus Retinitis Across the Immunosuppression Spectrum: A Contemporary Framework for Risk Stratification, Diagnosis, and Vision-Preserving Therapy.Journal of clinical medicine · 2026Review
- Ultra-widefield retinal imaging for early detection of asymptomatic cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation: a prospective pilot feasibility study.Journal of ophthalmic inflammation and infection · 2026Article
- CMV retinitis: the diagnostic challenges and long-term outcomes. The experience of tertiary eye center in Saudi Arabia.Journal of ophthalmic inflammation and infection · 2026Article
- A machine learning model for accurate prediction of CMV end-organ disease.BMC medical informatics and decision making · 2026Article
- Diabetes Mellitus is a Risk Factor for Developing CMV Retinitis in Solid Organ Transplant Recipients: A Case-control Study.Open forum infectious diseases · 2026Article
- The Use of CSF Multiplex PCR Panel in Patients with Viral Uveitis.Diagnostics (Basel, Switzerland) · 2026Article
- Infectious optic neuropathy: the interplay between pathogens and the host immune system-a review of diagnostic and therapeutic dilemmas.Frontiers in cellular and infection microbiology · 2026Review
- Efficacy of high-dose vs. low-dose intravitreal ganciclovir for cytomegalovirus retinitis: a systematic review and meta-analysis.Journal of Yeungnam medical science · 2026Article
- Vision-threatening ocular toxoplasmosis involving the fovea diagnosed by intraocular fluid mNGS: A case report.IDCases · 2026Article
- Bilateral Cytomegalovirus Retinitis With Co-infection of Epstein-Barr Virus and Varicella-Zoster Virus: A Rare Case.Cureus · 2025Article
- Eye on cytomegalovirus: Unveiling the ophthalmic impact of cytomegalovirus.World journal of virology · 2025Article
- Ocular drug delivery systems based on nanotechnology: a comprehensive review for the treatment of eye diseases.Discover nano · 2025Review
- Advances in Controlled Release Formulations for Ocular Diseases: Improving Patient Compliance and Therapeutic Outcomes.Current drug metabolism · 2025Review
- Investigation of the infection route of HIV-associated cytomegalovirus retinitis.International journal of ophthalmology · 2025Article
- Congenital cytomegalovirus retinitis of prematurity: a case report and literature review.Frontiers in pediatrics · 2025Article
- CMV Retinitis in the Context of SARS-CoV-2 Infection: A Case Study and Comprehensive Review of Viral Interactions.Pathogens (Basel, Switzerland) · 2024Review
- Cytomegalovirus retinitis with panretinal occlusive vasculopathy concealed by hypertensive uveitis: a case report.Journal of Yeungnam medical science · 2024Article
- Review
- Cytomegalovirus Retinitis in the Modern Era of Solid Organ Transplantation.Transplantation proceedings · 2024Article
- Endogenous endophthalmitis secondary to Lemierre's Syndrome originating from pharyngotonsillitis.Journal of ophthalmic inflammation and infection · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
purposeThe purpose of this study was to determine classification criteria for cytomegalovirus (CMV) retinitis.
designMachine learning of cases with CMV retinitis and 4 other infectious posterior/ panuveitides.
methodsCases of infectious posterior/panuveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on diagnosis using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used in the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the infectious posterior/panuveitides. The resulting criteria were evaluated in the validation set.
resultsA total of 803 cases of infectious posterior/panuveitides, including 211 cases of CMV retinitis, were evaluated by machine learning. Key criteria for CMV retinitis included: 1) necrotizing retinitis with indistinct borders due to numerous small satellites; 2) evidence of immune compromise; and either 3) a characteristic clinical appearance, or 4) positive polymerase chain reaction assay results for CMV from an intraocular specimen. Characteristic appearances for CMV retinitis included: 1) wedge-shaped area of retinitis; 2) hemorrhagic retinitis; or 3) granular retinitis. Overall accuracy for infectious posterior/panuveitides was 92.1% in the training set and 93.3% (95% confidence interval: 88.2-96.3) in the validation set. The misclassification rates for CMV retinitis were 6.9% in the training set and 6.3% in the validation set.
conclusionsThe criteria for CMV retinitis had a low misclassification rate and appeared to perform sufficiently well for use in clinical and translational research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.