ArticleAmerican journal of ophthalmology2021
Classification Criteria for Punctate Inner Choroiditis.
Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Intravitreal Dexamethasone Implant in Punctate Inner Choroidopathy: Clinical Indications and Outcomes in a Real-World Case Series.Ophthalmology and therapy · 2026Article
- Article
- Pathways to Patchy Atrophy in High Myopia: Precursor Patterns, Structural Characteristics, and Long-Term Outcomes.Ophthalmology science · 2026Article
- MEWDS-like Presentation Unmasking Sequential Bilateral Multifocal Choroiditis: Insights from Longitudinal Multimodal Imaging.Biomedicines · 2026Article
- Patterns of Inflammation in Experimental Autoimmune Uveitis and Their Correlation to Optical Coherence Tomography Findings in Human Uveitis.International journal of molecular sciences · 2026Article
- Atypical choroidal neovascular membrane.American journal of ophthalmology case reports · 2024Article
- Punctate Inner Choroiditis.Advances in ophthalmology and optometry · 2024Article
- Artificial intelligence in chorioretinal pathology through fundoscopy: a comprehensive review.International journal of retina and vitreous · 2024Review
- Artificial Intelligence in Uveitis: Innovations in Diagnosis and Therapeutic Strategies.Clinical ophthalmology (Auckland, N.Z.) · 2024Review
- The role of a multicentre data repository in ocular inflammation: The Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS).Eye (London, England) · 2023Review
- Association of Risk Variants in the CFH Gene With Elevated Levels of Coagulation and Complement Factors in Idiopathic Multifocal Choroiditis.JAMA ophthalmology · 2023Article
- The Conundrum of Clinical Trials for the Uveitides: Appropriate Outcome Measures for One Treatment Used in Several Diseases.Epidemiologic reviews · 2022Article
- The standardisation of uveitis nomenclature (SUN) project.Clinical & experimental ophthalmology · 2022Review
- [Development of classification criteria for uveitis by the standardization of uveitis nomenclature (SUN) working group].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Review
- Classification Criteria for Multifocal Choroiditis With Panuveitis.American journal of ophthalmology · 2021Article
- Development of Classification Criteria for the Uveitides.American journal of ophthalmology · 2021Article
- Central Multifocal Choroiditis: Platelet Granularity as a Potential Marker for Treatment With Steroid-Sparing Immunomodulatory Therapy.Frontiers in ophthalmology · 2021Article
- Optical Coherence Tomography Findings of Underlying Choroidal Neovascularization in Punctate Inner Choroidopathy.Frontiers in medicine · 2021Article
- An update of multimodal imaging in white dot syndrome.Oman journal of ophthalmologyReview
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1 author.
Funding
Abstract
purposeThe purpose of this study was to determine classification criteria for punctate inner choroiditis (PIC).
designMachine learning of cases with PIC and 8 other posterior uveitides.
methodsCases of posterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on diagnosis by using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used in the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the posterior uveitides. The resulting criteria were evaluated in the validation set.
resultsA total of 1,068 cases of posterior uveitides, including 144 cases of PIC, were evaluated by machine learning. Key criteria for PIC included: 1) "punctate"-appearing choroidal spots <250 µm in diameter; 2) absent to minimal anterior chamber and vitreous inflammation; and 3) involvement of the posterior pole with or without mid-periphery. Overall accuracy for posterior uveitides was 93.9% in the training set and 98.0% (95% confidence interval: 94.3-99.3) in the validation set. The misclassification rates for PIC were 15% in the training set and 9% in the validation set.
conclusionsThe criteria for PIC had a reasonably low misclassification rate and appeared to perform sufficiently well for use in clinical and translational research.
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