Evidence map›Paper›PMID 33845007›Full record

ArticleAmerican journal of ophthalmology2021

Classification Criteria for Fuchs Uveitis Syndrome.

Standardization of Uveitis Nomenclature (SUN) Working Group

Abstract read
In one paragraph

Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  8. Review
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  10. The standardisation of uveitis nomenclature (SUN) project.Clinical & experimental ophthalmology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Editorial: Multimodal imaging in uveitis.Frontiers in medicine · 2022
    Article
  16. [Here comes the "SUN" …].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021
    Article
  17. Viral anterior uveitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Standardization of Uveitis Nomenclature (SUN) Working Group

Funding

DEVELOPING CLASSIFICATION CRITERIA FOR THE UVEITIDESR01EY026593 · NEI · JOHNS HOPKINS UNIVERSITY · PI JABS, DOUGLAS A · 2016 to 2019
$1.5M
NEI NIH HHS R01 EY026593
6 · The paper itself

Abstract

purposeTo determine classification criteria for Fuchs' uveitis syndrome.

designMachine learning of cases with Fuchs' uveitis syndrome and 8 other anterior uveitides.

methodsCases of anterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used on the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the anterior uveitides. The resulting criteria were evaluated on the validation set.

resultsOne thousand eighty-three cases of anterior uveitides, including 146 cases of Fuchs' uveitis syndrome, were evaluated by machine learning. The overall accuracy for anterior uveitides was 97.5% in the training set and 96.7% in the validation set (95% confidence interval 92.4, 98.6). Key criteria for Fuchs' uveitis syndrome included unilateral anterior uveitis with or without vitritis and either: 1) heterochromia or 2) unilateral diffuse iris atrophy and stellate keratic precipitates. The misclassification rates for Fuchs' uveitis syndrome were 4.7% in the training set and 5.5% in the validation set, respectively.

conclusionsThe criteria for Fuchs' uveitis syndrome had a low misclassification rate and appeared to perform well enough for use in clinical and translational research.

Indexed as

AdolescentAdultFemaleFluorescein AngiographyFundus OculiHumansIrisMaleMiddle AgedUveitisYoung Adult

Identifiers

PMID33845007
PMCPMC8594748

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.