ArticleAmerican journal of ophthalmology2021
Classification Criteria for Toxoplasmic Retinitis.
Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Clinical performance of the multiplex solid-phase "Direct Strip PCR" for infectious uveitis: a multicenter diagnostic accuracy study.Japanese journal of ophthalmology · 2026Article
- Qualitative and Quantitative Assessment of Vitreous Inflammation in Uveitis: Current Limitations and Emerging Diagnostic Approaches.Diagnostics (Basel, Switzerland) · 2026Review
- Toxoplasma gondii retinochoroiditis associated with Epstein-Barr virus-induced retinal necrosis in an immunocompetent patient.Journal of ophthalmic inflammation and infection · 2026Article
- Double Trouble: An Uncommon Case of Ocular Toxoplasmosis in a Systemic Lupus Erythematosus (SLE) Patient.Cureus · 2026Article
- A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy for Human Toxoplasmosis: Performance, Populations, and Validation Gaps.Medical devices (Auckland, N.Z.) · 2026Review
- Assessing the Combined Diagnostic Value of Serum ACE Levels, Mantoux Test and Lymphopenia in Uveitis Patients from a Tertiary Eye Care Center in Southern India.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Interpretable multi-model deep learning framework for automated four-class diagnosis of ocular toxoplasmosis using fundus imaging.Scientific reports · 2025Article
- The Evolution of Artificial Intelligence in Ocular Toxoplasmosis Detection: A Scoping Review on Diagnostic Models, Data Challenges, and Future Directions.Infectious disease reports · 2025Review
- Article
- Artificial Intelligence-Based Uveitis Diagnosis Through Retinal Vasculature Analysis: A Paradigm Shift in Ocular Tuberculosis.Ophthalmology and therapy · 2025Article
- Clinical characteristics, visual acuity outcomes, and factors associated with loss of vision among patients with active ocular toxoplasmosis: A retrospective study in a Thai tertiary center.PLoS neglected tropical diseases · 2024Article
- The role of age in ocular toxoplasmosis: clinical signs of immunosenescence and inflammaging.Frontiers in medicine · 2024Article
- Active toxoplasma chorioretinitis in immunocompromised patients: a case series.Archive of clinical cases · 2024Article
- The role of a multicentre data repository in ocular inflammation: The Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS).Eye (London, England) · 2023Review
- Round bodies in the outer plexiform layer in eyes with active Toxoplasma retinochoroiditis.BMJ case reports · 2023Article
- The standardisation of uveitis nomenclature (SUN) project.Clinical & experimental ophthalmology · 2022Review
- [Development of classification criteria for uveitis by the standardization of uveitis nomenclature (SUN) working group].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Review
- Epidemiological spectrum of infectious uveitis in the Asia-Pacific.Taiwan journal of ophthalmologyReview
- Clinical characteristics, imaging features, and fate of punctate outer retinal toxoplasmosis lesions in immunocompetent cases of ocular toxoplasmosis.Taiwan journal of ophthalmologyArticle
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Abstract
purposeTo determine classification criteria for toxoplasmic retinitis.
designMachine learning of cases with toxoplasmic retinitis and 4 other infectious posterior uveitides / panuveitides.
methodsCases of infectious posterior uveitides / panuveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used on the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the infectious posterior uveitides / panuveitides. The resulting criteria were evaluated on the validation set.
resultsEight hundred three cases of infectious posterior uveitides / panuveitides, including 174 cases of toxoplasmic retinitis, were evaluated by machine learning. Key criteria for toxoplasmic retinitis included focal or paucifocal necrotizing retinitis and either positive polymerase chain reaction assay for Toxoplasma gondii from an intraocular specimen or the characteristic clinical picture of a round or oval retinitis lesion proximal to a hyperpigmented and/or atrophic chorioretinal scar. Overall accuracy for infectious posterior uveitides / panuveitides was 92.1% in the training set and 93.3% (95% confidence interval 88.2, 96.3) in the validation set. The misclassification rates for toxoplasmic retinitis were 8.2% in the training set and 10% in the validation set.
conclusionsThe criteria for toxoplasmic retinitis had a low misclassification rate and seemed to perform sufficiently well for use in clinical and translational research.
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