Evidence map›Paper›PMID 33844920›Full record

ArticleAnalytical chemistry2021

Comprehensive Analysis of DNA Adducts Using Data-Independent wSIM/MS

Scott J Walmsley, Jingshu Guo, Paari Murugan, Christopher J Weight, Jinhua Wang, Peter W Villalta, Robert J Turesky

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Frequent Detection of Abasic Sites andChemical research in toxicology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Mass Spectral Library for DNA Adductomics.Chemical research in toxicology · 2024
    Article
  10. A Novel Adductomics Workflow IncorporatingEnvironmental science & technology · 2024
    Article
  11. Article
  12. Article
  13. Pathways to Identify ElectrophilesChemical research in toxicology · 2022
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Scott J WalmsleyMasonic Cancer Center, University of Minnesota, Minneapolis 55455, Minnesota, United States.ORCID 0000-0003-2108-1121
Jingshu GuoMasonic Cancer Center, University of Minnesota, Minneapolis 55455, Minnesota, United States.ORCID 0000-0001-8987-6911
Paari MuruganDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455, Minnesota, United States.
Christopher J WeightGlickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland 44125, Ohio, United States.
Jinhua WangMasonic Cancer Center, University of Minnesota, Minneapolis 55455, Minnesota, United States.
Peter W VillaltaMasonic Cancer Center, University of Minnesota, Minneapolis 55455, Minnesota, United States.ORCID 0000-0002-0067-3083
Robert J TureskyMasonic Cancer Center, University of Minnesota, Minneapolis 55455, Minnesota, United States.ORCID 0000-0001-7355-9903
University of Minnesota · USCleveland Clinic · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Untargeted Analysis ResourceU2CES026533 · NIEHS · UNIVERSITY OF MINNESOTA · PI PETERSON, LISA A · 2015 to 2025
$14.0M
Chemical markers of heterocyclic aromatic amines for human biomonitoringR01CA122320 · NCI · WADSWORTH CENTER · PI TURESKY, ROBERT J. · 2007 to 2018
$4.8M
DNA adductomics of the urinary systemR01CA220367 · NCI · UNIVERSITY OF MINNESOTA · PI ROSENQUIST, THOMAS A, TURESKY, ROBERT J. · 2017 to 2022
$3.0M
New biomonitoring methodologies to measure DNA adducts in human tissuesR01ES019564 · NIEHS · WADSWORTH CENTER · PI TURESKY, ROBERT J. · 2011 to 2020
$2.8M
Kidney DNA AdductomicsR01ES030765 · NIEHS · UNIVERSITY OF MINNESOTA · PI BALBO, SILVIA, TURESKY, ROBERT J. · 2020 to 2024
$2.2M
Mass Spectrometric Analytical Collaborations with Members of the Masonic Cancer Center of the University of MinnesotaR50CA211256 · NCI · UNIVERSITY OF MINNESOTA · PI Peter William Villalta · 2016 to 2026
$2.1M
Development of a DNA Adductome DatabaseR03ES031188 · NIEHS · UNIVERSITY OF MINNESOTA · PI WALMSLEY, SCOTT J · 2019 to 2020
$165k
NCATS NIH HHS UL1 TR000114NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA122320NCI NIH HHS R01 CA220367NCI NIH HHS R50 CA211256NIEHS NIH HHS R01 ES019564NIEHS NIH HHS R01 ES030765NIEHS NIH HHS R03 ES031188NIEHS NIH HHS U2C ES026533
6 · The paper itself

Abstract

A novel software has been created to comprehensively characterize covalent modifications of DNA through mass spectral analysis of enzymatically hydrolyzed DNA using the neutral loss of 2'-deoxyribose, a nearly universal MS

Indexed as

DNADNA AdductsSpectrometry, Mass, Electrospray IonizationHumansMass SpectrometryNucleotidesXenobioticsDNADNA AdductsNucleotidesXenobiotics

Identifiers

PMID33844920
PMCPMC8675643
OpenAlexW3154622338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.