ArticlePLoS biology2021
Peroxiredoxin alleviates the fitness costs of imidacloprid resistance in an insect pest of rice.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Down-regulation of the PxJHE2 gene elevates juvenile hormone titers and compensates for fitness costs of Bt Cry1Ac resistance in Plutella xylostella (L.).Pest management science · 2026Article
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- From Digestion to Detoxification: Exploring Plant Metabolite Impacts on Insect Enzyme Systems for Enhanced Pest Control.Insects · 2025Review
- Nanocarrier-mediated RNAi ofFrontiers in plant science · 2025Article
- Function Analysis of Heme Peroxidase Genes, MpPxd2 and MpPxd4, Under Thiacloprid Exposure in the Neonicotinoid-ResistantAntioxidants (Basel, Switzerland) · 2024Article
- Proteomic Analysis to Understand the Promotive Effect of Ethanol on Soybean Growth Under Salt Stress.Biology · 2024Article
- The molecular dynamics between reactive oxygen species (ROS), reactive nitrogen species (RNS) and phytohormones in plant's response to biotic stress.Plant cell reports · 2024Review
- Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes.Nature communications · 2024Article
- Understanding Ameliorating Effects of Boron on Adaptation to Salt Stress in Arabidopsis.Plants (Basel, Switzerland) · 2024Article
- Insecticide resistance reduces the profitability of insect-resistant rice cultivars.Journal of advanced research · 2024Article
- Symbiotic bacteria confer insecticide resistance by metabolizing buprofezin in the brown planthopper, Nilaparvata lugens (Stål).PLoS pathogens · 2023Article
- AGenes · 2022Article
- Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical insecticides have been heavily employed as the most effective measure for control of agricultural and medical pests, but evolution of resistance by pests threatens the sustainability of this approach. Resistance-conferring mutations sometimes impose fitness costs, which may drive subsequent evolution of compensatory modifier mutations alleviating the costs of resistance. However, how modifier mutations evolve and function to overcome the fitness cost of resistance still remains unknown. Here we show that overexpression of P450s not only confers imidacloprid resistance in the brown planthopper, Nilaparvata lugens, the most voracious pest of rice, but also leads to elevated production of reactive oxygen species (ROS) through metabolism of imidacloprid and host plant compounds. The inevitable production of ROS incurs a fitness cost to the pest, which drives the increase or fixation of the compensatory modifier allele T65549 within the promoter region of N. lugens peroxiredoxin (NlPrx) in the pest populations. T65549 allele in turn upregulates the expression of NlPrx and thus increases resistant individuals' ability to clear the cost-incurring ROS of any source. The frequent involvement of P450s in insecticide resistance and their capacity to produce ROS while metabolizing their substrates suggest that peroxiredoxin or other ROS-scavenging genes may be among the common modifier genes for alleviating the fitness cost of insecticide resistance.
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