Evidence map›Paper›PMID 33844535›Full record

ArticleJournal of medicinal chemistry2021

Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and Beyond.

Yong Ai, Lucia Hwang, Alexander D MacKerell, Ari Melnick, Fengtian Xue

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Design and synthesis of novelFuture medicinal chemistry · 2025
    Article
  3. Article
  4. Advances in pyrazolo[1,5-RSC advances · 2025
    Review
  5. B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and Beyond.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Review
  8. The N-Terminal Part ofInternational journal of molecular sciences · 2023
    Article
  9. Discovery of anJournal of medicinal chemistry · 2023
    Article
  10. International journal of molecular sciences · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yong AiDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States.ORCID 0000-0002-7598-7992
Lucia HwangDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States.
Alexander D MacKerellDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States.ORCID 0000-0001-8287-6804
Ari MelnickDepartment of Hematology and Oncology, Weill Cornell Medical College, New York, New York 10021, United States.ORCID 0000-0002-8074-2287
Fengtian XueDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States.ORCID 0000-0002-4132-9887
University of Maryland, Baltimore · USCornell University · US

Funding

Macromolecular Conformational HeterogeneityR35GM131710 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI ALEXANDER D MACKERELL · 2019 to 2026
$6.2M
NIGMS NIH HHS R35 GM131710
6 · The paper itself

Abstract

B-cell lymphoma 6 (BCL6) is a master regulator of germinal center formation that produce antibody-secreting plasma cells and memory B-cells for sustained immune responses. The BTB domain of BCL6 (BCL6

Indexed as

Binding SitesBTB-POZ DomainDrug DesignHumansLymphoma, Large B-Cell, DiffuseMolecular Dynamics SimulationPeptide LibraryPeptidesProtein Interaction MapsProto-Oncogene Proteins c-bcl-6PyrimidinesSmall Molecule LibrariesBCL6 protein, humanPeptide LibraryPeptidesProto-Oncogene Proteins c-bcl-6PyrimidinesSmall Molecule Libraries

Identifiers

PMID33844535
PMCPMC8168288
OpenAlexW3156455992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.