ArticleJournal of the American Chemical Society2021
Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-of-Equilibrium Enzymatic Reactions.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Timed batch inputs unlock substantially higher yields for enzymatic cascades.Nature chemistry · 2026Article
- Electrochemical Synthesis of Methoxy-Molecules (Basel, Switzerland) · 2025Article
- Photoactivated Enzymatic Reaction Network Enables Spatiotemporal Programming of Thiol/Disulfide Redox Systems.Angewandte Chemie (International ed. in English) · 2025Article
- A Urease-Based pH Photoswitch: A General Route to Light-to-pH Transduction.Angewandte Chemie (International ed. in English) · 2025Article
- Ammonium Dinitramide as a Prospective N-NOMolecules (Basel, Switzerland) · 2024Article
- Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems.Chemical reviews · 2024Review
- Cell-Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non-/Out-of-Equilibrium Dynamic Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cascade nanozymatic network mimicking cells with selective and linear perception of HChemical science · 2023Article
- Mechanosensitive non-equilibrium supramolecular polymerization in closed chemical systems.Nature communications · 2023Article
- A Bayesian Approach to Extracting Kinetic Information from Artificial Enzymatic Networks.Analytical chemistry · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrasensitivity is a ubiquitous emergent property of biochemical reaction networks. The design and construction of synthetic reaction networks exhibiting ultrasensitivity has been challenging, but would greatly expand the potential properties of life-like materials. Herein, we exploit a general and modular strategy to reversibly regulate the activity of enzymes using light and show how ultrasensitivity arises in simple out-of-equilibrium enzymatic systems upon incorporation of reversible photoswitchable inhibitors (PIs). Utilizing a chromophore/warhead strategy, PIs of the protease α-chymotrypsin were synthesized, which led to the discovery of inhibitors with large differences in inhibition constants (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.