Evidence map›Paper›PMID 33844495›Full record

ArticleACS chemical neuroscience2021

Novel Peptide-Calix[4]arene Conjugate Inhibits Aβ Aggregation and Rescues Neurons from Aβ's Oligomers Cytotoxicity

Grazia Maria Letizia Consoli, Rita Tosto, Ausilia Baglieri, Salvatore Petralia, Tiziana Campagna, Giuseppe Di Natale, Stefania Zimbone, Maria Laura Giuffrida, Giuseppe Pappalardo

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Grazia Maria Letizia ConsoliCNR-Institute of Biomolecular Chemistry, Via P. Gaifami 18, 95126 Catania, Italy.ORCID 0000-0003-4189-930X
Rita TostoInternational PhD School of Chemical Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy.
Ausilia BaglieriCNR-Institute of Biomolecular Chemistry, Via P. Gaifami 18, 95126 Catania, Italy.
Salvatore PetraliaDepartment of Drug Sciences and Health, University of Catania, V.le A. Doria 6, 95125 Catania, Italy.ORCID 0000-0001-5692-1130
Tiziana CampagnaCNR-Institute of Crystallography, Via P. Gaifami 18, 95126 Catania, Italy.
Giuseppe Di NataleCNR-Institute of Crystallography, Via P. Gaifami 18, 95126 Catania, Italy.
Stefania ZimboneCNR-Institute of Crystallography, Via P. Gaifami 18, 95126 Catania, Italy.
Maria Laura GiuffridaCNR-Institute of Crystallography, Via P. Gaifami 18, 95126 Catania, Italy.
Giuseppe PappalardoCNR-Institute of Crystallography, Via P. Gaifami 18, 95126 Catania, Italy.ORCID 0000-0001-7328-3492
Institute of Crystallography · ITUniversity of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative condition affecting people in the elderly. Targeting aggregation of β-amyloid peptides (Aβ) is considered a promising approach for the therapeutic treatment of the disease. Peptide based inhibitors of β-amyloid fibrillation are emerging as safe drug candidates as well as interesting compounds for early diagnosis of AD. Peptide conjugation via covalent bond with functional moieties enables the resultant hybrid system to acquire desired functions. Here we report the synthesis, the structural characterization, and the Aβ

Indexed as

Alzheimer DiseasePeptide FragmentsAgedAmyloid beta-PeptidesCalixarenesHumansNeuronsPhenolsAmyloid beta-Peptidescalix(4)areneCalixarenesPeptide FragmentsPhenolsamyloidAβ oligomerscalixarenespeptidesSH-SY5Y cells

Identifiers

PMID33844495
PMCPMC9535895
OpenAlexW3155084104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.