Evidence map›Paper›PMID 33844445›Full record

ArticlePediatric blood & cancer2021

Esophageal disease among childhood cancer survivors-A report from the Childhood Cancer Survivors Study.

Peter H Asdahl, Kevin C Oeffinger, Vanna Albieri, Melissa Hudson, Wendy M Leisenring, Sarah S Donaldson, Henrik Hasle, Jeanette F Winther, Gregory T Armstrong, Leslie L Robison

Open access · goldAbstract read
In one paragraph

Article in Pediatric blood & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Late effects of the treatment of childhood cancer.World journal of clinical cases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Peter H AsdahlDepartment of Hematology Oeffinger, Aarhus University Hospital, Aarhus, Denmark.
Kevin C OeffingerDepartment of Medicine, Duke Cancer Institute, Durham, North Carolina, USA.
Vanna AlbieriUnit of Statistics and Data Analysis, Danish Cancer Society Research Center, Copenhagen, Denmark.
Melissa HudsonDepartments of Oncology and Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Wendy M LeisenringPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Sarah S DonaldsonDepartment of Radiation Oncology, Stanford University, Stanford, California, USA.
Henrik HasleDepartment of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
Jeanette F WintherChildhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
Gregory T ArmstrongDepartment of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Aarhus University Hospital · DKSt. Jude Children's Research Hospital · USDanish Cancer Society · DKDuke Cancer InstituteFred Hutch Cancer Center · USStanford University · US

Funding

Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

There is limited information addressing the occurrence of esophageal strictures among the growing population of survivors of childhood cancer. Using the Childhood Cancer Survivor Study, we analyzed data from 17,121 5-year survivors and 3400 siblings to determine the prevalence and risk factors for esophageal strictures. Prevalence among survivors was 2.0% (95% confidence interval [CI]: 1.8-2.2%), representing a 7.6-fold increased risk compared to siblings. Factors significantly associated with risk of esophageal stricture included diagnosis of Hodgkin lymphoma, greater chest radiation dose, younger age at cancer diagnosis, platinum chemotherapy, and hematopoietic stem cell transplantation. While uncommon, survivors are at risk for therapy-related esophageal strictures.

Indexed as

Cancer SurvivorsHodgkin DiseaseNeoplasmsChildConstriction, PathologicEsophageal DiseasesHumansRisk FactorsSurvivorschemotherapychildhood cancer survivorshipesophageal diseaseesophageal strictureradiation

Identifiers

PMID33844445
PMCPMC9124525
OpenAlexW3156286525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.