ArticleCancer2021
Metabolic imaging with hyperpolarized
Article in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07510607 (Assessing Metabolic Changes in Multiple Sclerosis Using Hyper-polarized Carbon 13 MRI), which is not on this map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing Metabolic Changes in Multiple Sclerosis Using Hyper-polarized Carbon 13 MRI
Who cites it
40 citing papers in PubMed, 55 citations in OpenAlex.
- Evaluating the metabolic effects of neoadjuvant treatment in clear cell renal cell carcinoma using hyperpolarized [1-Abdominal radiology (New York) · 2026Trial
- Hyperpolarized MRI in Oncology-A Review of Clinical Studies and Evaluation of Preclinical Liver Studies.NMR in biomedicine · 2026Review
- Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back-to-Back Neuroimaging and Blood Analysis.Magnetic resonance in medicine · 2026Article
- Ultra-low fieldCommunications chemistry · 2026Article
- Probing intratumoral metabolic compartmentalisation in a patient with fumarate hydratase-deficient renal cancer using clinical hyperpolarisedCommunications medicine · 2026Article
- Potential Clinical Applications of HyperpolarizedRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Consensus recommendations for hyperpolarized [1-Magnetic resonance in medicine · 2025Article
- Open-source implementation of X-nuclear sequences using the Pulseq framework.Magnetic resonance in medicine · 2025Article
- Potential of Metabolic MRI to Address Unmet Clinical Needs in Localised Kidney Cancer.Cancers · 2025Review
- Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarizedNpj imaging · 2025Article
- Advancements in early detection of pancreatic cancer: the role of artificial intelligence and novel imaging techniques.Abdominal radiology (New York) · 2025Review
- K-Means Clustering of HyperpolarisedCancers · 2025Article
- Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025Review
- A pharmacokinetic model for hyperpolarizedMagnetic resonance in medicine · 2024Article
- Article
- Long-lived enhanced magnetization-A practical metabolic MRI contrast material.Science advances · 2024Article
- Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024Review
- Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications.Korean journal of radiology · 2024Review
- HyperpolarizedMagnetic resonance in medicine · 2024Article
- Hyperpolarized [1-European radiology experimental · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOptimal treatment selection for localized renal tumors is challenging because of their variable biologic behavior and limitations in the preoperative assessment of tumor aggressiveness. The authors investigated the emerging hyperpolarized (HP)
methodsEleven patients with renal tumors underwent HP
resultsEight patients had tumors with a sufficient metabolite signal-to-noise ratio for analysis; an insufficient tumor signal-to-noise ratio was noted in 2 patients, likely caused by poor tumor perfusion and, in 1 patient, because of technical errors. Of the 8 patients, 3 had high-grade clear cell renal cell carcinoma (ccRCC), 3 had low-grade ccRCC, and 2 had chromophobe RCC. There was a trend toward a higher lactate-to-pyruvate ratio in high-grade ccRCCs compared with low-grade ccRCCs. Both chromophobe RCCs had relatively high lactate-to-pyruvate ratios. Good reproducibility was noted across the 5 patients who underwent 2 HP
conclusionsThe current results demonstrate the feasibility of HP LAY SUMMARY: Renal tumors are frequently discovered incidentally because of the increased use of medical imaging, but it is challenging to identify which aggressive tumors should be treated. A new metabolic imaging technique was applied to noninvasively predict renal tumor aggressiveness. The imaging results were compared with tumor samples taken during surgery and showed a trend toward differentiating between low-grade and high-grade clear cell renal cell carcinomas, which are the most common type of renal cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.