ArticleeLife2021
Distinct neuronal populations contribute to trace conditioning and extinction learning in the hippocampal CA1.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Hippocampal astrocytic sequences emerge during learning and memory recall.Nature neuroscience · 2026Article
- Hippocampal astrocytic sequences emerge during learning and memory.bioRxiv : the preprint server for biology · 2026Article
- Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics.Communications biology · 2025Article
- Assessment of retention and attenuation of motor-learning memory by repeated rotor-rod analyses.Scientific reports · 2024Article
- Beta-frequency sensory stimulation enhances gait rhythmicity through strengthened coupling between striatal networks and stepping movement.Nature communications · 2024Article
- Reactivation of encoding ensembles in the prelimbic cortex supports temporal associations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The blink reflex and its modulation - Part 1: Physiological mechanisms.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Review
- Neural dynamics underlying associative learning in the dorsal and ventral hippocampus.Nature neuroscience · 2023Article
- The autism spectrum disorder risk geneFrontiers in neuroscience · 2023Article
- Sustained Activity of Hippocampal Parvalbumin-Expressing Interneurons Supports Trace Eyeblink Conditioning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Enhanced fear limits behavioral flexibility in Shank2-deficient mice.Molecular autism · 2022Article
- Region-specific effects of ultrasound on individual neurons in the awake mammalian brain.iScience · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Trace conditioning and extinction learning depend on the hippocampus, but it remains unclear how neural activity in the hippocampus is modulated during these two different behavioral processes. To explore this question, we performed calcium imaging from a large number of individual CA1 neurons during both trace eye-blink conditioning and subsequent extinction learning in mice. Our findings reveal that distinct populations of CA1 cells contribute to trace conditioned learning versus extinction learning, as learning emerges. Furthermore, we examined network connectivity by calculating co-activity between CA1 neuron pairs and found that CA1 network connectivity patterns also differ between conditioning and extinction, even though the overall connectivity density remains constant. Together, our results demonstrate that distinct populations of hippocampal CA1 neurons, forming different sub-networks with unique connectivity patterns, encode different aspects of learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.