Evidence map›Paper›PMID 33843403›Full record

ArticleLeukemia & lymphoma2021

CXCR4 allows T cell acute lymphoblastic leukemia to escape from JAK1/2 and BCL2 inhibition through CNS infiltration.

Kirsti L Walker, Sean P Rinella, Nicholas J Hess, David P Turicek, Sabrina A Kabakov, Fen Zhu, Myriam N Bouchlaka, Sydney L Olson, Monica M Cho, Aicha E Quamine and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia & lymphoma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Kirsti L WalkerDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Sean P RinellaDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Nicholas J HessDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0001-5720-9305
David P TuricekDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Sabrina A KabakovDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Fen ZhuDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Myriam N BouchlakaDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Sydney L OlsonDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Monica M ChoDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Aicha E QuamineDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Arika S FeilsDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Tara B GavcovichDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Lixin RuiCarbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Christian M CapitiniDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0002-2276-6731
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Center for Eukaryotic Structural GenomicsP50GM064598 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 2001 to 2004
$23.7M
Training in Cancer Biology Training GrantT32CA009135 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SUGDEN, WILLIAM M. · 1985 to 2024
$10.4M
INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
NRSA Training CoreTL1TR002375 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Vivek Prabhakaran · 2017 to 2026
$8.4M
RESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2M
Epigenetic Gene Regulation by JAK1 Kinase in Diffuse Large B-Cell LymphomaR01CA187299 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI RUI, LIXIN · 2015 to 2019
$1.7M
Combining hu14.18-IL2 and NK cell infusions to treat neuroblastomaR01CA215461 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAPITINI, CHRISTIAN · 2018 to 2022
$1.7M
Isotope-Assisted Differential Metabolomics (RMI)R33DK070297 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI SUSSMAN, MICHAEL RICHARD · 2006 to 2006
$1.2M
Inhibiting STAT1 as a novel graft-versus-host/graft-versus-leukemia therapyK08CA174750 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAPITINI, CHRISTIAN · 2014 to 2017
$715k
NCATS NIH HHS TL1 TR002375NCI NIH HHS K08 CA174750NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA187299NCI NIH HHS R01 CA215461NCI NIH HHS T32 CA009135NHLBI NIH HHS T32 HL007899NIDDK NIH HHS R33 DK070297NIGMS NIH HHS P50 GM064598NIGMS NIH HHS T32 GM008692
6 · The paper itself

Abstract

Targeting the JAK/STAT and BCL2 pathways in patients with relapsed/refractory T cell acute lymphoblastic leukemia (T-ALL) may provide an alternative approach to achieve clinical remissions. Ruxolitinib and venetoclax show a dose-dependent effect on T-ALL individually, but combination treatment reduces survival and proliferation of T-ALL

Indexed as

Precursor T-Cell Lymphoblastic Leukemia-LymphomaReceptors, CXCR4BenzylaminesBridged Bicyclo Compounds, HeterocyclicCentral Nervous SystemCyclamsHematopoietic Stem Cell MobilizationHumansJanus Kinase 1NitrilesProto-Oncogene Proteins c-bcl-2PyrazolesPyrimidinesSulfonamidesBCL2 protein, humanBenzylaminesBridged Bicyclo Compounds, HeterocyclicCXCR4 protein, humanCyclamsJAK1 protein, humanJanus Kinase 1NitrilesplerixaforProto-Oncogene Proteins c-bcl-2PyrazolesPyrimidinesReceptors, CXCR4ruxolitinibSulfonamidesvenetoclaxacute lymphoblastic leukemiaBCL2JAK/STATplerixaforruxolitniibT cellvenetoclax

Identifiers

PMID33843403
PMCPMC8432301
OpenAlexW3154995688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.