Evidence map›Paper›PMID 33843249›Full record

ArticleJournal of the American Heart Association2021

Antenatal Hypoxia Affects Pulmonary Artery Contractile Functions via Downregulating L-type Ca

Huan Li, Bingyu Ji, Ting Xu, Meng Zhao, Yingying Zhang, Miao Sun, Zhice Xu, Qinqin Gao

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Effects of a postnatal high-salt diet on cardiac function in offspring from hypoxic pregnancies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Huan LiFrom the Institute for Fetology First Hospital of Soochow University Suzhou China.
Bingyu JiFrom the Institute for Fetology First Hospital of Soochow University Suzhou China.
Ting XuFrom the Institute for Fetology First Hospital of Soochow University Suzhou China.
Meng ZhaoFrom the Institute for Fetology First Hospital of Soochow University Suzhou China.
Yingying ZhangFrom the Institute for Fetology First Hospital of Soochow University Suzhou China.
Miao SunFrom the Institute for Fetology First Hospital of Soochow University Suzhou China.
Zhice XuFrom the Institute for Fetology First Hospital of Soochow University Suzhou China.
Qinqin GaoFrom the Institute for Fetology First Hospital of Soochow University Suzhou China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Antenatal intrauterine fetal hypoxia is a common pregnancy complication that has profound adverse effects on an individual's vascular health later in life. Pulmonary arteries are sensitive to hypoxia, but adverse effects of antenatal hypoxia on pulmonary vasoreactivities in the offspring remain unknown. This study aimed to determine the effects and related mechanisms of antenatal hypoxia on pulmonary artery functions in adult male offspring. Methods and Results Pregnant Sprague-Dawley rats were housed in a normoxic or hypoxic (10.5% O

Indexed as

Down-RegulationGene Expression RegulationPregnancy, AnimalAnimalsBlood PressureCalcium Channels, L-TypeCells, CulturedFemaleHypoxiaMaleMyocytes, Smooth MusclePregnancyPulmonary ArteryRatsRats, Sprague-DawleyRNACalcium Channels, L-TypeL-type calcium channel alpha(1C)RNAantenatal hypoxiaCav1.2male offspringvascular hypocontractility

Identifiers

PMID33843249
PMCPMC8174167
OpenAlexW3152644772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.