Evidence map›Paper›PMID 33843023›Full record

ArticlePharmacological reports : PR2021

Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.

Jakub Skałbania, Artur Pałasz, Iwona Błaszczyk, Aleksandra Suszka-Świtek, Marek Krzystanek, Karina Paola Tulcanaz, John J Worthington, Kinga Mordecka-Chamera

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological reports : PR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jakub SkałbaniaDepartment of Histology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.
Artur PałaszDepartment of Histology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland. apalasz@sum.edu.pl.ORCID http://orcid.org/0000-0002-2632-1211
Iwona BłaszczykDepartment of Histology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.
Aleksandra Suszka-ŚwitekDepartment of Histology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.
Marek KrzystanekClinic of Psychiatric Rehabilitation, Department of Psychiatry and Psychotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Ziołowa 45/47, 40-635, Katowice, Poland.
Karina Paola TulcanazFaculty of Medicine, Pontifical Catholic University of Ecuador, Av. 12 de Octubre 1076, 170143, Quito, Ecuador.
John J WorthingtonDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, LA1 4YQ, UK.
Kinga Mordecka-ChameraDepartment of Histology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.
Medical University of Silesia · PLLancaster University · GBPontificia Universidad Católica del Ecuador · EC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this structural study was to determine whether chronic chlorpromazine treatment affects adult neurogenesis in the canonical sites of the rat brain. At present, the clinical application of chlorpromazine is rather limited; however, it may still represent an important model in basic neuropharmacological and toxicological studies.

methodsThe number of neural progenitors and immature neurons was enumerated using immunofluorescent detection of Sox2, Musashi1 and doublecortin (DCX) expression within SVZ.

resultsChlorpromazine has a depressive effect on the early phase of adult neurogenesis in the rat subventricular zone (SVZ), as the mean number of Sox-2 immunoexpressing cells decreased following treatment.

conclusionCollectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.

Indexed as

AnimalsAntipsychotic AgentsCell ProliferationChlorpromazineDoublecortin ProteinHippocampusLateral VentriclesMaleNerve Tissue ProteinsNeural Stem CellsNeurogenesisNeuronsRatsRats, Sprague-DawleyRNA-Binding ProteinsSOXB1 Transcription FactorsAntipsychotic AgentsChlorpromazineDcx protein, ratDoublecortin ProteinMsi1 protein, ratNerve Tissue ProteinsRNA-Binding ProteinsSox2 protein, ratSOXB1 Transcription FactorsAdult neurogenesisChlorpromazineRatsSubventricular zone

Identifiers

PMID33843023
PMCPMC8413197
OpenAlexW3153645393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.