Evidence map›Paper›PMID 33842991›Full record

ArticleArchives of gynecology and obstetrics2021

Pregnancy outcomes in women with a hemoglobinopathy trait: a multicenter, retrospective study.

Jan Kasparek, Tilo Burkhardt, Irene Hoesli, Gabriela Amstad Bencaiova

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03837119 (Maternal and Perinatal Pregnancy Outcome in Women With Heterozygous Hemoglobinopathies), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03837119 completednot on this map

Maternal and Perinatal Pregnancy Outcome in Women With Heterozygous Hemoglobinopathies

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2018 to 2021Enrolled540ConditionsHeterozygous HaemoglobinopathyArmspregnancy outcome
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jan KasparekDepartment of Obstetrics and Antenatal Care, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Tilo BurkhardtDepartment of Obstetrics and Antenatal Care, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.
Irene HoesliDepartment of Obstetrics and Antenatal Care, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Gabriela Amstad BencaiovaDepartment of Obstetrics and Antenatal Care, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland. gabriela.amstad@usb.ch.ORCID 0000-0002-1661-5056

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the risk of adverse maternal and neonatal outcomes in pregnant women with a hemoglobinopathy trait. MATERIALS AND

methodsRetrospective cohort study was conducted to compare adverse maternal and neonatal outcomes between pregnant women with a hemoglobinopathy trait (study group; n = 172), and without a hemoglobinopathy trait (control group; n = 360). The medical data were extracted from clinical records of pregnant women attending antenatal care and delivering at the University Hospital Basel or University Hospital Zurich between 2015 and 2018.

resultsA total of 172 pregnant women with a hemoglobinopathy trait and 360 controls were recruited. Apart from fetal acidosis, the groups did not differ significantly in any variables of adverse neonatal outcomes. Whereas, among the maternal outcomes the rate of abortion, gestational diabetes mellitus, bacteriuria or urinary tract infection, intrahepatic cholestasis, abnormal placentation and anemia postpartum were significantly increased in women with a hemoglobinopathy trait.

conclusionIn our study, a hemoglobinopathy trait increased the risk of adverse maternal outcomes but did not increase adverse neonatal outcomes.

Indexed as

AcidosisAdolescentAdultBacteriuriaCase-Control StudiesFemaleHemoglobinopathiesHumansInfant, NewbornMiddle AgedPregnancyPregnancy Complications, HematologicPregnancy OutcomeRetrospective StudiesYoung AdultHemoglobinopathy traitMaternal outcomesNeonatal outcomesPregnancy

Identifiers

PMID33842991
PMCPMC8490217

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