ArticleInternational journal of reproductive biomedicine2021
Synbiotic (FamiLact) administration in idiopathic male infertility enhances sperm quality, DNA integrity, and chromatin status: A triple-blinded randomized clinical trial.
Article in International journal of reproductive biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Is Lactobacillus spp. beneficial in human semen? Systematic review.JBRA assisted reproduction · 2025Pooled it
- Probiotics supplementation in the treatment of male infertility: A Systematic Review.JBRA assisted reproduction · 2024Pooled it
- Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial.Iranian journal of medical sciences · 2026Trial
- Gut-testis axis: how microbiota influence male reproductive health.Asian biomedicine : research, reviews and news · 2026Review
- Gut microbiota and their role in male reproductive health.NPJ science of food · 2026Review
- Addition of lactic acid bacteria to diluted ram semen as vehicle for vaginal inoculation: interaction with seminal microbiota, sperm quality and antibacterial in vitro effect against Mycoplasma agalactiae.BMC veterinary research · 2026Article
- The influence and mechanism of gut microbiota on spermatogenesis.Cell biology and toxicology · 2026Review
- Probiotics as Microbiome Modulators in Male Infertility: Rethinking Dysbiosis Across the Gut-Testis Axis.Journal of personalized medicine · 2026Review
- Transgenerational exposure to plastics-derived endocrine-disrupting bisphenol A and its analogs on male infertility: impact of gut dysbiosis and epigenetic regulation.Frontiers in endocrinology · 2026Review
- Research progress on the multidimensional mechanisms underlying impaired spermatogenesis induced by pathological microenvironment remodeling in chronic prostatitis.Frontiers in immunology · 2026Review
- Nutritional modulation of the gut-reproductive axis: multi-strain probiotic blend on oxidative and seminal parameters in healthy male dogs.Frontiers in veterinary science · 2026Article
- The Androbactome and the Gut Microbiota-Testis Axis: A Narrative Review of Emerging Insights into Male Fertility.International journal of molecular sciences · 2025Review
- Impact of Dietary Probiotics on the Immune and Reproductive Physiology of Pubertal Male Japanese Quail (Coturnix coturnix japonica) Administered at the Onset of Pre-Puberty.Probiotics and antimicrobial proteins · 2025Article
- A PRISMA Systematic Review of Sexual Dysfunction and Probiotics with Pathophysiological Mechanisms.Biology · 2025Review
- Diabetic testicular dysfunction and spermatogenesis impairment: mechanisms and therapeutic prospects.Frontiers in endocrinology · 2025Review
- Causal Link between Gut Microbiota and Infertility: A Two-sample Bidirectional Mendelian Randomization Study.Current medical science · 2024Article
- Male Tract Microbiota and Male Infertility.Cells · 2024Review
- Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility.Biology · 2024Review
- Review
- Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions.Frontiers in immunology · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdiopathic male infertility is often treated empirically. A recent body of evidence has indicated the association between pro
objectiveTo assess the effect of FamiLact (probiotic + prebiotic) administration on male subjects with idiopathic infertility. MATERIALS AND
methodsFifty-six men with idiopathic male infertility were randomly/equally divided into two groups. Men in the case and control groups received 500 mg of FamiLact and an identical placebo for 80 days, respectively. A semen sample was obtained from each of the participants before initiation and after the termination of the treatment course. Samples underwent regular semen analysis and were further analyzed to assess the level of DNA damage (sperm chromatin structure assay), oxidative stress (BODIPY C11 staining), and protamine deficiency (chromomycin-A3 staining) in spermatozoa.
resultsNo significant difference was observed between the baseline values of both groups. After intervention, mean sperm concentration, motility, and normal morphology were significantly higher in the FamiLact group compared to the placebo group (p
conclusionFamiLact administration improves sperm concentration, motility, and abnormal morphology and decrease sperm DNA damage, possibly through alleviating oxidative stress in the seminal fluid.
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