Evidence map›Paper›PMID 33842472›Full record

ArticleFrontiers in cell and developmental biology2021

Adipose-Derived Stromal Cell-Sheets Sandwiched, Book-Shaped Acellular Dermal Matrix Capable of Sustained Release of Basic Fibroblast Growth Factor Promote Diabetic Wound Healing.

Xin Shi, Liyuan Jiang, Xin Zhao, Bei Chen, Wei Shi, Yanpeng Cao, Yaowu Chen, Xiying Li, Yusheng He, Chengjie Li and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Xin ShiThe First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Liyuan JiangKey Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.
Xin ZhaoThe First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Bei ChenDepartment of Limbs (Foot and Hand) Microsurgery, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, China.
Wei ShiDepartment of Emergency, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Yanpeng CaoDepartment of Limbs (Foot and Hand) Microsurgery, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, China.
Yaowu ChenDepartment of Limbs (Foot and Hand) Microsurgery, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, China.
Xiying LiDepartment of Limbs (Foot and Hand) Microsurgery, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, China.
Yusheng HeDepartment of Limbs (Foot and Hand) Microsurgery, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, China.
Chengjie LiDepartment of Limbs (Foot and Hand) Microsurgery, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, China.
Xiaoren LiuDepartment of Limbs (Foot and Hand) Microsurgery, Affiliated Chenzhou Hospital, Southern Medical University, Chenzhou, China.
Xing LiKey Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.
Hongbin LuKey Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.
Can ChenKey Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.
Jun LiuThe First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Chenzhou First People's Hospital · CNSouthern Medical University · CNCentral South University · CNHubei Provincial Hospital of Traditional Chinese Medicine · CNSoil and Fertilizer Institute of Hunan Province · CNXiangnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of diabetic wounds is a therapeutic challenge in clinical settings. Current tissue engineering strategies for diabetic wound healing are insufficient, owing to the lack of an appropriate scaffold that can load a large number of stem cells and induce the interaction of stem cells to form granulation tissue. Herein we fabricated a book-shaped decellularized dermal matrix (BDDM), which shows a high resemblance to native dermal tissue in terms of its histology, microstructure, and ingredients, is non-cytotoxic and low-immunogenic, and allows adipose-derived stromal cell (ASC) attachment and proliferation. Then, a collagen-binding domain (CBD) capable of binding collagen was fused into basic fibroblast growth factor (bFGF) to synthetize a recombinant growth factor (termed as CBD-bFGF). After that, CBD-bFGF was tethered onto the collagen fibers of BDDM to improve its endothelial inducibility. Finally, a functional scaffold (CBD-bFGF/BDDM) was fabricated.

Indexed as

adipose-derived stromal cellscollagen-binding domaindecellularized dermal matrixdiabetic wound healingfibroblast growth factor

Identifiers

PMID33842472
PMCPMC8027315
OpenAlexW3151140632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.