Evidence map›Paper›PMID 33842456›Full record

ReviewFrontiers in cell and developmental biology2021

Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response.

Robert Gilkerson, Patrick De La Torre, Shaynah St Vallier

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 123 citations in OpenAlex.

  1. Article
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  3. Specific FbioRxiv : the preprint server for biology · 2026
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  12. Mitochondrial Calcium Signaling in Hepatocyte Health and Disease.Cold Spring Harbor perspectives in biology · 2026
    Review
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Robert GilkersonDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, United States.
Patrick De La TorreDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, United States.
Shaynah St VallierDepartment of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, United States.
The University of Texas Rio Grande Valley · US

Funding

Interaction of mitochondrial fusion and transmembrane potential in diabetic cardiovascular damageSC3GM116669 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI GILKERSON, ROBERT W · 2016 to 2023
$872k
NIGMS NIH HHS SC3 GM116669
6 · The paper itself

Abstract

Mammalian mitochondria are emerging as a critical stress-responsive contributor to cellular life/death and developmental outcomes. Maintained as an organellar network distributed throughout the cell, mitochondria respond to cellular stimuli and stresses through highly sensitive structural dynamics, particularly in energetically demanding cell settings such as cardiac and muscle tissues. Fusion allows individual mitochondria to form an interconnected reticular network, while fission divides the network into a collection of vesicular organelles. Crucially, optic atrophy-1 (OPA1) directly links mitochondrial structure and bioenergetic function: when the transmembrane potential across the inner membrane (ΔΨ

Indexed as

apoptosisdevelopmentmitochondriaOMA1OPA1

Identifiers

PMID33842456
PMCPMC8027119
OpenAlexW3141251867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.