Evidence map›Paper›PMID 33842334›Full record

ArticleFrontiers in oncology2021

Cancer Associated Fibroblasts Promote Renal Cancer Progression Through a TDO/Kyn/AhR Dependent Signaling Pathway.

Li-Bo Chen, Shun-Ping Zhu, Tian-Pei Liu, Heng Zhao, Ping-Feng Chen, You-Jun Duan, Rong Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Modeling CAF-tumor interactions to overcome therapy resistance.Journal of experimental & clinical cancer research : CR · 2026
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  10. Article
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  13. The Tumor Immune Microenvironment in Clear Cell Renal Cell Carcinoma.International journal of molecular sciences · 2023
    Review
  14. Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment.Journal of experimental & clinical cancer research : CR · 2023
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Li-Bo ChenDepartment of Urology, The First Affiliated Hospital of University of South China, Hengyang, China.
Shun-Ping ZhuDepartment of Respiratory, The First Affiliated Hospital of University of South China, Hengyang, China.
Tian-Pei LiuDepartment of Urology, The First Affiliated Hospital of University of South China, Hengyang, China.
Heng ZhaoDepartment of Radiology, The First Affiliated Hospital of University of South China, Hengyang, China.
Ping-Feng ChenDepartment of Urology, The First Affiliated Hospital of University of South China, Hengyang, China.
You-Jun DuanDepartment of Urology, The First Affiliated Hospital of University of South China, Hengyang, China.
Rong HuDepartment of Radiology, The First Affiliated Hospital of University of South China, Hengyang, China.
First Affiliated Hospital of University of South China · CNUniversity of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer associated fibroblasts (CAFs) play crucial roles in cancer development, however, the specific mechanisms of CAFs associated renal cancer progression remain poorly understood. Our study observed enriched CAFs in high degree malignant tumor tissues from renal cancer patients. These CAFs isolated from tumor tissues are prone to facilitate drugs resistance and promote tumor progression

Indexed as

3-dioxygenase (TDO)aromatic hydrocarbon receptorcancer associated fibroblastskynureninerenal cancertryptophan 2

Identifiers

PMID33842334
PMCPMC8027476
OpenAlexW3141640839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.