Evidence map›Paper›PMID 33842236›Full record

ArticleGland surgery2021

Oncological outcomes of lipofilling in breast reconstruction: a matched cohort study with 250 patients.

Jose M Casarrubios, Mónica Francés, Victor Fuertes, Margit Singer, Carlos Navarro, Orlando García-Duque, Javier Fernández-Palacios

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gland surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. [Research progress of external volume expansion assisted autologous fat grafting for breast reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jose M CasarrubiosDepartment of Plastic, Reconstructive & Aesthetic Surgery, University Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain.
Mónica FrancésDepartment of Plastic, Reconstructive & Aesthetic Surgery, University Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain.
Victor FuertesDepartment of Plastic, Reconstructive & Aesthetic Surgery, University Hospital Miguel Servet, Zaragoza, Spain.
Margit SingerDepartment of Plastic, Reconstructive & Aesthetic Surgery, University Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain.
Carlos NavarroDepartment of Plastic, Reconstructive & Aesthetic Surgery, University Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain.
Orlando García-DuqueDepartment of Plastic, Reconstructive & Aesthetic Surgery, University Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain.
Javier Fernández-PalaciosDepartment of Plastic, Reconstructive & Aesthetic Surgery, University Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain.
Hospital Universitario de Gran Canaria Doctor Negrín · ESHospital Universitario Miguel Servet · ESUniversidad de Las Palmas de Gran Canaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFat grafting is a procedure commonly used in breast reconstruction nowadays. Nevertheless, its oncological safety remains controversial. The potential risk that progenitor cells included in fat graft tissue may contribute to disease progression in patients with breast cancer is still debatable. We have designed a matching-cohort study with 250 patients with history of breast cancer trying to elucidate an answer for this question.

methodsWe selected 250 patients with a history of breast cancer in our hospital, between 2011 and 2019. A total of 125 patients (cases) had a history of breast cancer reconstructed with fat grafting. The additional 125 patients are matched controls. We analyzed the distribution of eight different variables within the cases and their matched controls: date of first oncological surgery, age, type of oncological surgery, histological subtype, Her-2 status, pN, smoking habit and diabetes mellitus. The objective of this study was to analyze the influence of fat grafting over breast cancer recurrence.

resultsThere are not statistically significant differences in breast cancer locoregional recurrences (P=0.183), distant metastases (P=0.200) or total recurrences (P=0.065) amongst the two groups (cancer cases and matched controls).

conclusionsOur study adds more information over the oncological safety of fat grafting. These findings should encourage long-term prospective trials to provide surgeons with accurate information regarding the role of lipofilling on breast neoplasms.

Indexed as

breast cancerbreast reconstructionfat graftingLipofillingoncological safety

Identifiers

PMID33842236
PMCPMC8033056
OpenAlexW3146894190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.